Enhancement of HIV Env specific antibody responses by intrastructural help from heterologous T helper cells (21)

Gag特异性辅助性T细胞通过结构内辅助机制增强含Gag和Env的病毒样颗粒（VLP）加强免疫小鼠后的Env抗体应答。目前项目的目的是利用这种结构内的帮助来调节异源T辅助细胞对HIV Env的抗体反应。在用内部含有异源抗原的VLP加强免疫之前，将针对异源抗原免疫小鼠。通过使用针对异源抗原的不同引发模式，我们的目标是调节对HIV Env的体液免疫应答，特别关注诱导粘膜免疫应答

Gag-specific T-helper cells increase the Env antibody response in mice after booster immun-izations with virus-like particles (VLPs) containing Gag and Env by the intrastructural help mechanism. The aim of the current project is to exploit this intrastructural help to modulate the antibody response to HIV Env by heterologous T helper cells. Mice will be immunized against heterologous antigens prior to booster immunizations with VLPs containing the heterologous antigens inside. By using different modes of priming against the heterologous antigens, we aim to modulate the humoral immune response to the HIV Env with a particular focus on inducing mucosal immune responses