Functional coupling between frontal cortex and auditory cortex in echolocating bats

回声定位蝙蝠额叶皮层和听觉皮层之间的功能耦合

• 批准号: 275755787
• 负责人: Dr. Julio Hechavarria
• 金额: --
• 依托单位: Institut für Zellbiologie und Neurowissenschaft
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/275755787?language=en
• 关键词: Functional; coupling; between; frontal; cortex

Auditory and frontal cortices interact with one another during sound production and processing, and these interactions are a fundamental component of the hearing-action cycle. In a previous project (grant HE 7478/1-1) we studied the dynamics of activation between frontal and auditory cortex areas of the bat brain. Our findings produced data for 8 articles (6 published, 1 submitted and 1 under preparation). These articles dealt with neural oscillations in the frontal cortex - auditory cortex (AC) network of bats, and the involvement of this network in vocal production and sound analysis in passive listening settings. The present proposal is thought as an elongation of the aforementioned grant. We propose two work-packages (W1 and W2) aimed to continue studying neural activity in the bat frontal-AC circuit. In W1, we will assess acoustic periodicity coding and stimulus specific adaptation in frontal and AC areas of awake bats. Such “network” approach for studying sound coding in the bat brain is unprecedented. In W2, neural activity will be studied during echolocation production induced by placing bats on a swinging pendulum. Studying the neural correlates of vocal production in bats swung on a pendulum will allow us to assess the neural underpinnings of vocalization in acoustically controlled cocktail-party-like scenarios created in the lab. The experiments proposed will produce original data which will advance knowledge on basic mechanisms of bat echolocation, but also on general principles of cortical interactions for auditory coding and vocalization behavior in mammals.

听觉和额叶皮质在声音产生和处理过程中相互作用，这些相互作用是听觉-动作循环的基本组成部分。在以前的项目（授予HE 7478/1-1），我们研究了蝙蝠大脑额叶和听觉皮层区域之间的激活动力学。我们的研究结果为8篇文章提供了数据（6篇已发表，1篇已提交，1篇正在编写）。这些文章涉及蝙蝠额叶皮层-听觉皮层（AC）网络中的神经振荡，以及该网络在被动听力环境中的发声和声音分析中的参与。目前的建议被认为是上述赠款的延伸。我们提出了两个工作包（W1和W2），旨在继续研究蝙蝠额叶AC电路的神经活动。在W1中，我们将评估清醒蝙蝠的额叶和AC区的声学周期性编码和刺激特异性适应。这种研究蝙蝠大脑中声音编码的“网络”方法是前所未有的。在W2中，神经活动将被研究在回声定位生产过程中，通过将蝙蝠摆在摆动的钟摆上。研究蝙蝠在钟摆上摆动时发声的神经相关性，将使我们能够评估实验室中创建的声学控制鸡尾酒会式场景中发声的神经基础。提出的实验将产生原始数据，这将促进蝙蝠回声定位的基本机制的知识，但也对哺乳动物的听觉编码和发声行为的皮质相互作用的一般原则。