CAD/CAM composite vs ceramic minimal invasive therapeutical intervention of severe non carious lesions: Clinical performance and quality of life improvement

CAD/CAM 复合材料与陶瓷微创治疗干预严重非龋齿：临床表现和生活质量改善

• 批准号: 276467384
• 负责人: Professorin Dr. Petra Christine Gierthmühlen
• 金额: --
• 依托单位: Poliklinik für Zahnärztliche Prothetik
• 依托单位国家: 德国
• 项目类别: Clinical Trials
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/276467384?language=en
• 关键词: CAD; CAM; composite; vs; ceramic

Dental erosion is recognized as a global public oral health problem leading to significant aesthetic and functional impairments of affected patients. Anterior and posterior teeth in the upper and lower jaw reveal extensive tooth substance loss. Restoring such teeth with conventional metal-ceramic full-coverage crowns frequently involves elective endodontic therapy, surgical crown lengthening procedures and major additional loss of tooth structure. Minimal invasive manually fabricated restorations were hence developed, but are ¿ due to their high costs ¿ not available to the majority of patients. New techniques based on computer aided design/manufacturing (CAD/CAM) could introduce an innovative approach for minimal invasive and yet affordable restorations, making oral health available to a wide patient population. To date, high-level evidence on their clinical behaviour is lacking. Therefore the present application proposes a randomized controlled non-inferiority multicentre prospective clinical trial. The mid-term performance of patients with severe erosive lesions after therapeutical intervention with minimal invasive CAD/CAM fabricated composite restorations will be compared to manually produced minimal invasive all-ceramic restorations. The impact on patient´s quality of life and patient-centred satisfaction with the aesthetic and functional treatment outcome will be addressed. If the new CAD/CAM approach shows comparable results to manually produced restorations, this technique could become the standard of care with a high accessibility to a wider patient clientele.

牙齿侵蚀被认为是一个全球性的公共口腔健康问题，导致受影响的患者的显着的美学和功能障碍。上下颌的前牙和后牙显示出广泛的牙质损失。用传统的金属-陶瓷全覆盖冠修复这些牙齿通常涉及选择性牙髓治疗，外科牙冠延长术和牙齿结构的主要额外损失。因此开发了微创手动制造的手术，但由于其成本高，大多数患者无法获得。基于计算机辅助设计/制造（CAD/CAM）的新技术可以引入一种创新的方法，用于微创且负担得起的口腔修复，使广大患者群体能够获得口腔健康。迄今为止，缺乏关于其临床行为的高级别证据。因此，本申请提出了一项随机对照非劣效性多中心前瞻性临床试验。严重侵蚀性病变患者在使用微创CAD/CAM制造的复合修复体进行治疗干预后的中期表现将与手工制作的微创全瓷修复体进行比较。将讨论对患者生活质量的影响以及以患者为中心的美学和功能治疗结果满意度。如果新的CAD/CAM方法显示出与手动制作的简化相当的结果，则该技术可能成为更广泛的患者客户的高可及性的护理标准。