Role of IDO in resolution of inflammatory autoimmune responses by CD83-induced regulatory mechanisms in arthritis (B03)

B03项目（Steinkasserer）将进一步研究cd83诱导的吲哚胺-2,3-双加氧酶- (IDO)代谢在炎症消退中的作用。在第一个资助期，CD83被确定为一个关键因子，它不仅刺激IDO的生物合成，还触发炎症的消退。在CRC1181的第二期，B03项目将遵循CD83激活调节氨基酸和短链脂肪酸代谢从而促进炎症解决的概念。

Project B03 (Steinkasserer) will extend its work regarding the role of CD83-induced indoleamine-2,3-dioxygenase- (IDO) metabolism in resolution of inflammation. In the first funding period CD83 was identified as a key factor that not only stimulates the biosynthesis of IDO but also triggers resolution of inflammation. In the second phase of CRC1181, project B03 will follow the concept that CD83 activation modulates amino acid and short chain fatty acid metabolism and thereby facilitates resolution of inflammation.