Mechanisms mediating circadian leukocyte recruitment to arteries and veins (B09*)

该项目的目标是阐明白细胞以有节奏的方式附着在动脉和静脉上的机制上的差异和相似之处。我们将研究炎性白细胞聚集到大口径血管以及静脉和小动脉微循环。我们将评估微动脉环境中缺乏节律性是否会改变静脉循环中白细胞的募集行为。我们将结合遗传学方法、药物干预以及外科去神经技术来研究驱动白细胞黏附节律的潜在机制。

The goal of the project is to elucidate mechanistic differences and similarities in the ways that leukocytes adhere to arteries and veins in a rhythmic manner. We will investigate inflammatory leukocyte recruitment to large-caliber blood vessels as well as to the venous and arteriolar microcirculation. We will assess whether lack of rhythmicity in an arteriolar environment can alter the recruitment behavior of leukocytes in the venous circulation. We will combine genetic approaches with pharmacological interventions as well as surgical denervation techniques to examine the underlying mechanism driving leukocyte adhesion rhythms.