Inflammation and fibrogenesis in early lesions of chronic lung allograft dysfunction (B09*)

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Project B09 will characterize bronchiolitis obliterans (BOS) on the molecular level. During a DFG funded project headed by D. Jonigk, they identified a specific expression pattern helpful in diagnosing and even predicting the subsequent development of BOS. The molecular pattern rather described effector mechanisms of a fibrogenic tissue response. Therefore, the group aims to identify the early BOS lesions to test the double-hit hypothesis in human lung grafts. According to this model, BO develops in an alloimmune setting when a secondary initiating damage like mucosal damage by ischemia or infection occurs. Finally, the group will use a recently established rat lung transplant model mimicking the development of BOS. The model will be used to test various therapeutic interventions preventing (antibiotics, immunosuppression) the development of BOS, which could pave the way for future clinical trials.