Dynamics of the Photoswitch-Process of Hemithioindigo and Hemiindigo (A12*)

在SFB 749中，我们的目标是开发新的基于HTI和HI的光开关，具有强红移吸收（>500 nm），同时保持亚稳E异构体状态的高热稳定性。还将进行手性HI衍生物的第一次研究。此外，我们计划研究HTIs与DNA的超分子结合以及如何光控DNA杂交。为此，我们将用插入动机和DNA碱基取代HTI的核心结构。在这种情况下，我们还将研究DNA的刚性环境如何影响光异构化过程。

Within the SFB 749 we aim to develop new HTI and HI based photoswitches with strongly redshifted absorption (>500 nm), while maintaining a high thermal stability of the metastable E isomeric state. The first studies of chiral HI derivatives will also be undertaken. In addition we plan to investigate the supramolecular binding of HTIs to DNA and how DNA hybridization can be photocontrolled. To this end, we will substituted the core structure of HTI with intercalation motives and DNA bases. In this context we will also study how the rigid environment of DNA influences the photoisomerization process.