Novel tractography-guided MRI methods for studying healthy brain ageing

成像技术的进步，尤其是磁共振成像技术的进步，开启了大脑研究的新纪元，使无数的神经科学发现成为可能。该项目旨在开发新的分析方法来研究和理解人类大脑在衰老过程中的变化，利用所谓的神经束图（一种大脑线路图）中包含的丰富信息。该项目希望开发创新的成像生物标志物，以表征健康大脑衰老过程中的大脑变化。预期的结果包括神经科学的新型成像工具，这将使我们能够绘制规范健康大脑衰老的轨迹，并利用它们来识别影响这些轨迹的生活方式因素。

Advances in imaging, and particularly Magnetic Resonance Imaging, have opened a new era in the study of the brain enabling a myriad of neuroscience discoveries. This project aims to develop new analysis methods to study and understand the variability in the human brain during ageing, exploiting the wealth of information contained in the so-called tractogram, a mapping of the brain’s wiring. This project expects to develop innovative imaging biomarkers to characterise the brain changes in the course of healthy brain ageing. Expected outcomes include novel imaging tools for neuroscience, which should allow us to map trajectories of normative healthy brain ageing and use them to identify lifestyle factors that impact these trajectories.