Novel tractography-guided MRI methods for studying healthy brain ageing

用于研究健康大脑衰老的新型纤维束成像引导 MRI 方法

• 批准号: DP240102161
• 负责人: Prof Fernando Calamante
• 金额: $ 32.46万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102161
• 关键词: Novel; tractography; guided; MRI; methods

Advances in imaging, and particularly Magnetic Resonance Imaging, have opened a new era in the study of the brain enabling a myriad of neuroscience discoveries. This project aims to develop new analysis methods to study and understand the variability in the human brain during ageing, exploiting the wealth of information contained in the so-called tractogram, a mapping of the brain’s wiring. This project expects to develop innovative imaging biomarkers to characterise the brain changes in the course of healthy brain ageing. Expected outcomes include novel imaging tools for neuroscience, which should allow us to map trajectories of normative healthy brain ageing and use them to identify lifestyle factors that impact these trajectories.

成像技术的进步，特别是磁共振成像，开辟了大脑研究的新时代，使无数的神经科学发现成为可能。该项目旨在开发新的分析方法，以研究和了解人类大脑在衰老过程中的变化，利用所谓的tractogram中包含的丰富信息，这是一种大脑布线图。该项目旨在开发创新的成像生物标志物，以揭示健康大脑衰老过程中的大脑变化。预期成果包括神经科学的新型成像工具，这应该使我们能够绘制出正常健康大脑老化的轨迹，并利用它们来识别影响这些轨迹的生活方式因素。