The role of the transcription factor Runx2 during mammary gland development and lactation

这一建议将进一步加深我们对乳腺发育和泌乳以及控制乳腺细胞分化等命运决定的机制的理解。细胞命运的调控是细胞生物学从正常发育到功能障碍（如癌症）的大多数方面的核心。从这个项目中获得的知识也有可能通过提高盈利能力和确保乳制品和肉类行业的可持续性来为澳大利亚创造经济收益。更好地了解控制乳腺上皮细胞分化的机制应该能够通过标记辅助选择（靶点如Runx2）在牛中增加乳蛋白含量等方式来增加泌乳量。

This proposal will further our understanding of mammary gland development and lactation and the mechanisms controlling mammary cell fate decisions such as differentiation. Regulation of cell fate lies at the core of most aspects of cell biology from normal development to dysfunction such as cancer. The knowledge gleamed from this project also has the potential to make economic gains for Australia by increasing the profitability and ensuring the sustainability of both the dairy and meat industries. Better understanding of the mechanisms controlling mammary epithelial cell differentiation should enable augmentation of lactation such as increasing milk protein content, using marker assisted selection (of targets such as Runx2) in cattle.