From regulation of alternative translation initiation to other aspects of post-transcriptional gene regulation: functional analyses of Sex-lethal and related proteins (B11)

从选择性翻译起始的调控到转录后基因调控的其他方面：性致死蛋白和相关蛋白的功能分析（B11）

• 批准号: 278579334
• 金额: --
• 依托单位: Lehrstuhl für Biochemie I
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/278579334?language=en
• 关键词: regulation; alternative; translation; initiation; other

The Drosophila RNA-binding protein Sex-lethal (Sxl) is the master regulator of female development in somatic tissues. Numerous regulatory mechanisms operate to tightly control its sex- specific expression and to restrict its activity to female animals. Our aim is to understand in more detail how Sxl expression is regulated and how Sxl and related proteins exert their post-transcriptional regulatory activity on a molecular level.

果蝇RNA结合蛋白Sex-lethal（Sxl）是果蝇体细胞组织中雌性发育的主要调节因子。许多调节机制起作用以严格控制其性别特异性表达并将其活性限制在雌性动物中。我们的目的是更详细地了解Sxl表达是如何调节的，以及Sxl和相关蛋白如何在分子水平上发挥其转录后调节活性。