Theoretical and computational approaches to accurately predict the structures of a unique family of circular and knotted proteins.

准确预测独特的环状和打结蛋白家族结构的理论和计算方法。

• 批准号: DP0773830
• 负责人: Dr Quentin Kaas
• 金额: $ 18.25万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0773830
• 关键词: Theoretical; computational; approaches; accurately; predict

The primary outcome will be a fundamental new knowledge on cyclotide structures and a new protein engineering method to design stabilised proteins. Because cyclotides have significantly higher stabilities than conventional proteins, they have a range of pharmaceutical and agricultural applications. Both fields of use have the potential for very great economic and social benefits for Australia. From a pharmaceutical perspective our computing development will greatly facilitate the design of stabilised peptide-based drugs using the cyclotide framework. Such drugs have potential sales of several billion dollars per annum and the royalty returns from successful commercialisation of IP can be substantial.

主要成果将是对环肽结构的基本新知识和设计稳定蛋白质的新蛋白质工程方法。由于环肽比常规蛋白质具有显著更高的稳定性，因此它们具有一系列制药和农业应用。这两个使用领域都有可能为澳大利亚带来巨大的经济和社会效益。从制药的角度来看，我们的计算发展将大大促进稳定的肽为基础的药物使用环肽框架的设计。这些药物每年的潜在销售额为数十亿美元，知识产权成功商业化的特许权使用费回报可能很可观。