Serine ubiquitination and regulation of autophagy upon Legionella (E01 (C01))

点击翻译按钮获取中文摘要

We will examine the impact of serine ubiquitination on the host autophagic pathway and how this might affect bacterial infection by Legionella. We will perform functional studies to elucidate the contribution of Legionella SidE proteins and RavZ in impairing host autophagy. We will use super-resolution microscopy to study the nanoscale protein organization around the Legionella-containing vacuole, focusing on autophagy, signaling proteins, and ubiquitination. We will develop a functional, spatiotemporal and molecular picture of processes that guard Legionella from autophagy-mediated clearance.