Cytolytic CD4 T cell-mediated viral selection pressure: Defining potential strategies for therapeutic and prophylactic HIV vaccines (B09)

溶细胞 CD4 T 细胞介导的病毒选择压力：定义治疗性和预防性 HIV 疫苗的潜在策略 (B09)

• 批准号: 284242792
• 金额: --
• 依托单位: Institut für Virologie
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/284242792?language=en
• 关键词: Cytolytic; CD4; cell; mediated; viral

The role of CD4 T cells in the control of chronic viral infections is well established. Besides helper functions for CD8 T cells and B cells, non-traditional CD4 T cell functions have been implicated to significantly contribute to the control of viral infections including influenza, HBV and HIV. In this grant proposal we plan to determine 1.) the mechanisms involved in the induction of CD4 T cell-mediated cytotoxicity, 2.) the properties of the synapse formation and cytolytic pathways of CD4 T cells as well as the influence of inhibitory receptors on the synapse formation and 3.) we will reveal genetic regions of cytolytic CD4 T cell immune selection in the virus sequence and the consequence of these mutations on viral fitness. Overall, this grant proposal is designed to determine the mechanisms of cytolytic induction and function of CD4 T cells and their contribution to viral evolution and selection pressure in chronic HIV infection.

CD4T细胞在控制慢性病毒感染中的作用已经得到了充分的证实。除了CD8T细胞和B细胞的辅助功能外，非传统的CD4T细胞功能也被认为对控制包括流感、乙肝病毒和艾滋病毒在内的病毒感染做出了重大贡献。在这项赠款提案中，我们计划确定1。)CD4T细胞介导的细胞毒作用的诱导机制。CD4T细胞突触形成和细胞溶解途径的特性以及抑制性受体对突触形成的影响。我们将揭示病毒序列中细胞溶解的CD4T细胞免疫选择的遗传区域以及这些突变对病毒适合性的影响。总体而言，这项赠款提案旨在确定CD4T细胞的细胞溶解诱导和功能机制，以及它们在慢性艾滋病毒感染中对病毒进化和选择压力的贡献。