Sex differences in stress coping and anxiety: role of the brain CRF system
压力应对和焦虑的性别差异:大脑 CRF 系统的作用
基本信息
- 批准号:289097011
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Research Fellowships
- 财政年份:2015
- 资助国家:德国
- 起止时间:2014-12-31 至 2016-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
During my research stay in the laboratory of Dr. Victor Viau at the University of British Columbia I will investigate the sex-specific role of the corticotropin-releasing factor (CRF) system in stress coping and the process of habituation to repeated stressor exposition as well as the sex-specific regulation of anxiety-related behavior by the CRF system in male and female rats. To date, most neuroscientific research has focused on males. However, accumulating evidence points to a higher prevalence of females to develop pathophysiologies. This sexual dimorphism is particularly prevailing in the context of stress, which I started to address already in my PhD thesis. I demonstrated that female rats respond more sensitive to CRF and show increased anxiety-related behavior than male rats. Furthermore, it is known that females adapt less to repeated stressor exposition which is most likely based on the distinct expression of gonadal hormones and central neuropeptide systems. This leads to my hypothesis stating that the CRF system as main initiator of the stress axis plays a central and sexually dimorph role in the process of habituation to stress and the expression of anxiety. During my postdoctoral research stay in the laboratory of Dr. Viau, I aim to address these questions via neuroanatomical combined with neuropharmacological and neuroendocrine approaches eliciting potential mechanisms underlying both research questions.
在不列颠哥伦比亚大学维克多·维奥博士的实验室进行研究期间,我将研究促肾上腺皮质激素释放因子(CRF)系统在压力应对中的性别特异性作用、对重复应激源暴露的适应过程,以及CRF系统对雄性和雌性大鼠焦虑相关行为的性别特异性调节。迄今为止,大多数神经科学研究都集中在男性身上。然而,越来越多的证据表明,女性患上病理生理疾病的比例更高。这种两面性在压力背景下尤其普遍,我已经在我的博士论文中开始讨论这一点。我证明,雌性大鼠对CRF的反应比雄性大鼠更敏感,并表现出更多的焦虑相关行为。此外,众所周知,女性对重复的应激源暴露的适应程度较低,这很可能是基于性腺激素和中枢神经肽系统的不同表达。这导致了我的假设,CRF系统作为应激轴的主要发起者,在适应压力和表达焦虑的过程中发挥着中心和性变异的作用。我在Viau博士的实验室从事博士后研究期间,我的目标是通过神经解剖学结合神经药理学和神经内分泌方法解决这些问题,从而引出这两个研究问题的潜在机制。
项目成果
期刊论文数量(0)
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Dr. Stefanie Meister其他文献
Dr. Stefanie Meister的其他文献
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