身体活動関連バイオマーカーと潜在的脳血管病変との関連に関する疫学的検討

体力活动相关生物标志物与潜在脑血管病变关系的流行病学研究

• 批准号: 21J14861
• 负责人: MONIRUZZAMAN
• 金额: $ 1.25万
• 依托单位: Shiga University of Medical Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for JSPS Fellows
• 财政年份: 2021
• 资助国家: 日本
• 起止时间: 2021-04-28 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21J14861/
• 关键词: Serum Irisin Levels; Aging brain diseases; Exercise; Physical activity; Brain health

I have completed all the planned activities (prepare relevant datasets, perform preliminary analyses, and share results with supervisors) within the stipulated time (Apr to Sep 2021). Moreover, I have finalized the abstract ( approved by co-authors) and submitted it to the 32nd Annual Scientific Meeting of the Japan Epidemiological Association for presentation. Currently, I am drafting the manuscript.Key results: We found a J-shaped relationship between serum irisin levels and total cerebral small vessel disease burden in healthy Japanese men. Serum irisin levels were also related to reduced risk of periventricular hyperintensities, lacunar infracts, and cerebral microbleeds, but not deep and subcortical white matter hyperintensities. This is the first study to examine such associations.

我已在规定时间内（2021年4月至9月）完成所有计划活动（准备相关数据集，进行初步分析，并与主管分享结果）。此外，我已经完成了摘要（由共同作者批准），并将其提交给日本流行病学协会第32届年度科学会议进行介绍。目前，我正在起草手稿。关键结果：我们发现了一个J形的关系血清鸢尾素水平和总脑小血管疾病的负担在健康的日本男性。血清鸢尾素水平也与降低脑室周围高信号、腔隙性梗死和脑微出血的风险相关，但与深部和皮质下白色物质高信号无关。这是第一次研究这种关联。

项目成果

Relationship Between Serum Irisin Levels and MRI-measured Cerebral Small Vessel Disease Burden in Japanese Men

日本男性血清鸢尾素水平与 MRI 测量的脑小血管疾病负担之间的关系

• 发表时间: 2022
• 作者: Mohammad Moniruzzaman;Aya Kadota;Takashi Hisamatsu;Hiroyoshi Segawa;Keiko Kondo;Sayuki Torii;Naoko Miyagawa;Akira Fujiyoshi;Yoshiyuki Watanabe;Akihiko Shiino;Kazuhiko Nozaki;Hirotsugu Ueshima;Katsuyuki Miura;for the SESSA Research Group
• 通讯作者: for the SESSA Research Group