Role of mitochondrial quality control in hepatic encephalopathy (B09)

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Hepatic encephalopathy (HE) is a neuropsychatric syndrome caused by various forms of liver dysfunction. Resulting hyperammonemia leads to modulation of autophagy/ mitophagy and rapid metabolic reprogramming in astrocytes. In this context, we aim to better understand the mechanistic role of mitochondrial quality control, focusing on mitophagy and autophagy, and of energy metabolism for the pathogenesis of HE. For this we will use suitable in vitro-, organoid-, and in vivo-models. Thereby, we hope to find novel strategies for HE treatment.