FOR 806: Interfering with Intracellular Protein-protein Interactions - Probing Protein Functions with Small Molecules

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The assorted flow of information within cellular pathways largely relies on reversible and specific protein-protein interactions. In many instances, they often involve extended, relatively flat protein surfaces, which cannot easily be blocked by small molecules. Therefore, pharmacological interference by targeting intracellular protein-protein interactions is an especially demanding task, requiring research at the interface of molecular biology and chemistry.