A Crosstalk Between Inflammation and Epigenetics in Regulating HSC Fitness

炎症与表观遗传学在调节 HSC 健康方面的串扰

• 批准号: 21K06870
• 负责人: HUANG Gang
• 金额: $ 2.66万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2021
• 资助国家: 日本
• 起止时间: 2021-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21K06870/
• 关键词: Hematopoietic stem cell; Inflammation; Epigenetics; Stress; SETD2; MYD88

The functionality of hematopoietic stem cell (HSC) compartment hinges on the limited reversible balance between quiescence and activation. The identity of cell-intrinsic mechanisms required to terminate activation and re-enter dormancy, and the signaling pathways that mediate this transition, remain unresolved key questions. Based on our data, we propose that “A crosstalk between inflammation and epigenetics controls HSC fitness” through nucleocytoplasmic shuttling of an E3 ubiquitin ligase Speckle-type POZ protein (SPOP) functioning in MYD88 or SETD2 degradation.

造血干细胞（HSC）室的功能取决于静止和激活之间有限的可逆平衡。终止激活和重新进入休眠所需的细胞内在机制的身份，以及介导这一转变的信号通路，仍然是未解决的关键问题。根据我们的数据，我们提出“炎症和表观遗传学之间的串音控制HSC适应度”，通过核细胞质穿梭E3泛素连接酶斑点型POZ蛋白（SPOP）在MYD88或SETD2降解中发挥作用。

项目成果

HMGA2 maintains hematopoietic stem cell via pleiotropic regulation of the transcription in stress conditions

HMGA2 通过在应激条件下转录的多效性调节来维持造血干细胞

• 发表时间: 2021
• 作者: Sho Kubota;Yuqi Sun;Jie Bai;Takako Yokomizo-Nakano;Mariko Morii;Takako Ideue;Motomi Osato;Terumasa Umemoto;Kimi Araki;Goro Sashida
• 通讯作者: Goro Sashida

シンシナティ小児病院/テキサス大学サンアントニオ(米国)

辛辛那提儿童医院/德克萨斯大学圣安东尼奥分校（美国）

ＵＴヘルスサンアントニオ(米国)

UT Health 圣安东尼奥（美国）