Development of a patient-personalized synapse proteomics technology for advancing precision diagnosis of mental disorders

开发患者个性化突触蛋白质组学技术以推进精神疾病的精确诊断

• 批准号: 21K07554
• 负责人: TAOUFIQ Zacharie
• 金额: $ 2.5万
• 依托单位: Okinawa Institute of Science and Technology Graduate University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2021
• 资助国家: 日本
• 起止时间: 2021-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21K07554/
• 关键词: Synapse; Deep proteomics; Schizophrenia; Mental disorders; iPS-derived neurons; iPSC-derived neurons; proteomics; psychiatry; diagnosis; biomarkers

In collaboration with the Budapest Research Center for Natural Sciences, I have received analyzed 3 new iPSC samples coming from Caucasian family having a living schizophrenia individual. The synapse proteomics analysis revealed significant impaired expression of some specific lipid metabolic enzymes compared healthy.I have started a collaboration with RIKEN AIP for building AI/Machine learning tools to interpret and analyze synapse proteomics data from our psychiatric patient cohort.

在与布达佩斯自然科学研究中心的合作下，我收到了3个新的IPSC样本，这些样本来自一个患有精神分裂症的高加索家庭。Synapse蛋白质组学分析显示，与健康相比，一些特定的脂代谢酶的表达明显受损。我已经开始与RIKEN AIP合作，构建人工智能/机器学习工具，以解释和分析来自我们精神疾病患者队列的Synapse蛋白质组学数据。

项目成果

‘Molecular anatomy of brain synapses from living psychiatric patients’

“活体精神病患者脑突触的分子解剖学”

• 发表时间: 2022
• 作者: 西村拡起;古宮淳一;Zacharie Taoufiq
• 通讯作者: Zacharie Taoufiq

Molecular anatomy of brain synapses from living psychiatric patients’

活体精神病患者脑突触的分子解剖学

• 发表时间: 2021
• 作者: Hosoda Yutaka;Ohtani Toshiyuki;Hanazawa Hisashi;Tanaka Mami;Kimura Hiroshi;Ohsako Noriaki;Hashimoto Tasuku;Kobori Osamu;Iyo Masaomi;Nakazato Michiko;Zacharie Taoufiq
• 通讯作者: Zacharie Taoufiq

International Symposium on Artificial Intelligence and Brain Science

人工智能与脑科学国际研讨会

• 发表时间: 2022
• 作者: Noriko Numata;Akiko Nakagawa;Kazuko Yoshioka;Kayoko Isomura;Daisuke Matsuzawa;Rikukage Setsu;Michiko Nakazato & Eiji Shimizu;Zacharie Taoufiq
• 通讯作者: Zacharie Taoufiq

Novel peptide drug for treating Alzheimer’s disease.

治疗阿尔茨海默病的新型肽药物。

• 发表时间: 2022

Molecular anatomy of brain synapses from living psychiatric patients.

活体精神病患者脑突触的分子解剖学。

• 发表时间: 2021
• 作者: Noriko Numata;Akiko Nakagawa;Kazuko Yoshioka;Kayoko Isomura;Daisuke Matsuzawa;Rikukage Setsu;Michiko Nakazato & Eiji Shimizu;Zacharie Taoufiq;Zacharie Taoufiq
• 通讯作者: Zacharie Taoufiq