高炭酸ガス吸入が運動時の呼吸応答と脳波に及ぼす影響

吸入高碳酸血症对运动时呼吸反应和脑电波的影响

• 批准号: 21K11463
• 负责人: 加藤 貴英
• 金额: $ 2.33万
• 依托单位: National Institute of Technology, Toyota College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2021
• 资助国家: 日本
• 起止时间: 2021-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21K11463/
• 关键词: 高炭酸ガス; 低酸素; 換気; 脳波; 運動; 高炭酸ガス換気応答; 低酸素換気応答; 高炭酸ガス吸入; 呼吸応答; 酸素摂取量; 二酸化炭素排出量

【目的】動脈血二酸化炭素分圧の上昇および動脈血酸素分圧の低下は呼吸中枢を刺激して換気を亢進させる．そのため，高炭酸ガス（高濃度CO2）吸入下および低酸素吸入下における運動中の呼吸応答は空気吸入下と比較して異なる応答を示す．本研究では，高炭酸ガス吸入および低酸素吸入が運動時の呼吸応答に及ぼす影響について脳波解析を加えて検証することを目的として実験を行った．【実施内容】20歳代の男性被験者を対象に，3条件下で自転車エルゴメーターを用いた一定負荷運動実験を中強度（最大負荷の45％程度）と高強度（最大負荷の80％程度）でそれぞれ実施した．3条件については，1）空気吸入，2）高炭酸ガス吸入（酸素濃度21％，二酸化炭素濃度3％，窒素バランス），3）低酸素吸入（酸素濃度16％，窒素バランス），とした．実験プロトコールは，運動前安静10分，運動6分，運動回復6分であった．事前に3条件下で最大運動負荷試験を実施し，負荷強度を決定した．運動中の呼吸応答指標は自動呼気ガス分析器を用いて，脳波はワイヤレス脳波計を用いて記録した．今年度（2022年度）は7名の被験者から中強度および高強度運動中の呼吸応答指標と脳波を記録することができた．記録した脳波を周波数解析した結果，高強度負荷運動中のα波のパワースペクトルにおいてガス吸入条件に対する統計的有意差が見られ，換気増大を促す呼吸中枢の働きが運動強度により変化する可能性が示唆された．

The increase of arterial acidification carbon pressure and the decrease of arterial acidification carbon pressure stimulate the respiratory center and increase the respiratory rate. High carbon dioxide (high CO2) inhalation and low carbon dioxide inhalation, respiratory response during exercise, and air inhalation. The purpose of this study is to investigate the effects of high and low carbon inhalation on respiratory response during exercise and to analyze the effects of high carbon and low carbon inhalation on respiratory response during exercise. [Implementation] 20-year-old male female subject, under 3 conditions, self-driving, exercise with a certain load, exercise intensity (45% of maximum load) and high intensity (80% of maximum load) may be applied under different conditions, 1) air inhalation, 2) high carbon inhalation (acid concentration 21%, diacidified carbon concentration 3%, oxygen inhalation), 3) low acid inhalation (acid concentration 16%, oxygen inhalation). Before exercise quiet 10 points, exercise 6 points, exercise recovery 6 points. The maximum exercise load test under three conditions is carried out in advance, and the load intensity is determined. Breathing indicators during exercise are recorded in the automatic call analyzer. This year (2022), 7 people were injured, and breathing indicators and waves were recorded in moderate and high-intensity sports. As a result of the analysis of the frequency of the alpha wave and the frequency of the alpha wave during high-intensity exercise, statistical intentional differences in the inhalation conditions of the alpha wave during high-intensity exercise were observed, indicating the possibility that increased ventilation may promote respiratory center activity and vary depending on exercise intensity.