Elucidation of the novel epigenetic mechanism promoting a subset of hematologic malignancies

阐明促进血液系统恶性肿瘤的新表观遗传机制

• 批准号: 20K07346
• 负责人: UEDA Takeshi
• 金额: $ 2.83万
• 依托单位: Kindai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K07346/
• 关键词: エピジェネティクス; 遺伝子発現制御; 造血器腫瘍

项目成果

CD34+ myeloma cells with self-renewal activities are therapy-resistant and persist as MRD in cell cycle quiescence.

具有自我更新活性的 CD34+ 骨髓瘤细胞具有治疗抵抗性，并且在细胞周期静止中持续存在 MRD。

• DOI: 10.1007/s12185-021-03261-0
• 发表时间: 2022
• 期刊: Int J Hematol.
• 作者: Bell Katharina;Mori Kazuhiko;lkeda Yoko;Nakano Masakazu;Ueno Morio;Kinoshita Shigeru;Tashiro Kei;Sotozono Chie;Aung Tin et al.;Serizawa K; Tanaka H; Ueda T; Fukui A; Kakutani H; Taniguchi T; Inoue H; Kumode T; Taniguchi Y; Rai S; Hirase C; Morita Y; Espinoza JL; Tatsumi Y; Ashida T; Matsumura I
• 通讯作者: Serizawa K; Tanaka H; Ueda T; Fukui A; Kakutani H; Taniguchi T; Inoue H; Kumode T; Taniguchi Y; Rai S; Hirase C; Morita Y; Espinoza JL; Tatsumi Y; Ashida T; Matsumura I

UTX maintains functional integrity of murine hematopoietic system by globally regulating aging-associated genes.

UTX 通过全局调节衰老相关基因来维持小鼠造血系统的功能完整性。

• DOI: 10.1182/blood.2019001044
• 发表时间: 2021
• 期刊: Blood.
• 作者: 秀 道広;Mette Deleuran;藤田 浩之;有馬 和彦;Marius Ardeleanu;秀 道広;秀 道広;秀 道広;秀 道広;秀 道広;森桶 聡/秀 道広;田中美幸,RowaidaAlahmadi,中沢洋三;Sera Y; Nakata Y; Ueda T; Yamasaki N; Koide S; Kobayashi H; Ikeda KI; Kobatake K; Iwasaki M; Oda H; Wolff L; Kanai A; Nagamachi A; Inaba T; Sotomaru Y; Ichinohe T; Koizumi M; Miyakawa Y; Honda ZI; Iwama A; Suda T; Takubo K; Honda H
• 通讯作者: Sera Y; Nakata Y; Ueda T; Yamasaki N; Koide S; Kobayashi H; Ikeda KI; Kobatake K; Iwasaki M; Oda H; Wolff L; Kanai A; Nagamachi A; Inaba T; Sotomaru Y; Ichinohe T; Koizumi M; Miyakawa Y; Honda ZI; Iwama A; Suda T; Takubo K; Honda H

MYC/Glutamine Dependency Is a Therapeutic Vulnerability in Pancreatic Cancer with Deoxycytidine Kinase Inactivation-Induced Gemcitabine Resistance

• DOI: 10.1158/1541-7786.mcr-22-0554
• 发表时间: 2023-05-01
• 期刊: MOLECULAR CANCER RESEARCH
• 影响因子: 5.2
• 作者: Dash, Suman;Ueda, Takeshi;Okada, Hitoshi
• 通讯作者: Okada, Hitoshi

Ascorbate sensitizes human osteosarcoma cells to the cytostatic effects of cisplatin

• DOI: 10.1002/prp2.632
• 发表时间: 2020-08-01
• 期刊: PHARMACOLOGY RESEARCH & PERSPECTIVES
• 影响因子: 2.6
• 作者: Oka, Naohiro;Komuro, Akiyoshi;Okada, Hitoshi
• 通讯作者: Okada, Hitoshi

Kdm6a Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with p53 Dysfunction

• DOI: 10.1158/1078-0432.ccr-19-2230
• 发表时间: 2020-04-01
• 期刊: CLINICAL CANCER RESEARCH
• 影响因子: 11.5
• 作者: Kobatake, Kohei;Ikeda, Ken-ichiro;Honda, Hiroaki
• 通讯作者: Honda, Hiroaki