Identification of cancer suppressor genes that suppress tumorigenesis by mutant KRAS- involvement in pancreatic cancer

鉴定通过突变 KRAS 参与胰腺癌抑制肿瘤发生的抑癌基因

• 批准号: 20K07436
• 负责人: Sato Ikurou
• 金额: $ 2.66万
• 依托单位: Miyagi Prefectural Hospital Organization Miyagi Cancer Center
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K07436/
• 关键词: 舌癌; マウス発がん実験; PP6; KRAS; 膵がん; Kras; Trp53; プロテインホスファターゼ

项目成果

Ppp6c haploinsufficiency accelerates UV-induced BRAF(V600E)-initiated melanomagenesis.

• DOI: 10.1111/cas.14895
• 发表时间: 2021-06
• 期刊: Cancer science
• 影响因子: 5.7
• 作者: Kanazawa K;Kishimoto K;Nomura M;Kurosawa K;Kato H;Inoue Y;Miura K;Fukui K;Yamashita Y;Sato I;Tsuji H;Watanabe T;Tanaka T;Yasuda J;Tanuma N;Shima H
• 通讯作者: Shima H

PP6 deficiency in mice with KRAS mutation and Trp53 loss promotes early death by PDAC with cachexia-like features.

• DOI: 10.1111/cas.15315
• 发表时间: 2022-05
• 期刊: Cancer science
• 影响因子: 5.7