Development of a technique to noninvasively study the structure of in vivo vasculature in rodent brain using oscillating-gradient spin-echo diffusion-weighted magnetic resonance imaging

开发一种使用振荡梯度自旋回波扩散加权磁共振成像非侵入性研究啮齿动物大脑体内脉管系统结构的技术

• 批准号: 20K08150
• 负责人: Jeffrey Kershaw
• 金额: $ 2.75万
• 依托单位: National Institutes for Quantum Science and Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K08150/
• 关键词: OGSE; diffusion-weighted MRI; frequency domain; asymptotic behaviour; structural universality; diffusion MRI

Our efforts over the past year include continued revision and other activity towards the publication of our second manuscript, which focusses on understanding the asymptotic high- and low-frequency limits of the signal when measured with OGSE-DWI. Based on the results in this manuscript a presentation was made at the ISMRM Japan Chapter meeting in Nagoya (Sept 10-11, 2022).We have also extended our work on the ADC measured with OGSE-DWI. In particular, it has been demonstrated that the dynamic exponent characterising the global organisation of a medium may be systematically underestimated. This fact will be the core result in a presentation to be made at the ISMRM conference in Toronto in June 2023.

我们在过去一年中的努力包括继续修订和其他活动，以出版我们的第二份手稿，重点是了解用OGSE-DWI测量时信号的渐近高频和低频极限。基于本文的结果，在名古屋举行的ISMRM日本分会会议（2022年9月10日至11日）上进行了演示。我们还扩展了使用OGSE-DWI测量ADC的工作。特别是，它已被证明，动态指数表征的全球组织的介质可能被系统地低估。这一事实将成为2023年6月在多伦多举行的ISMRM会议上发表演讲的核心成果。

项目成果

Structural universalityand the oscillating-gradient spin-echo diffusion-weighted imaging sequence

结构普适性和振荡梯度自旋回波扩散加权成像序列

• 发表时间: 2022
• 作者: 加藤太一;足立史郎;Jeff Kershaw
• 通讯作者: Jeff Kershaw

Oscillating-gradient spin-echo diffusion-weighted imaging (OGSE-DWI) with a limited number of oscillations: I. Signal equation

具有有限振荡次数的振荡梯度自旋回波扩散加权成像（OGSE-DWI）：I.信号方程

• DOI: 10.1016/j.jmr.2021.106962
• 发表时间: 2021
• 期刊: Journal of Magnetic Resonance
• 影响因子: 2.2
• 作者: Kershaw Jeff;Obata Takayuki
• 通讯作者: Obata Takayuki