Selection of bone marrow ALDH bright cells for treatment of pulmonary fibrosis focusing on changes in bone marrow characteristics

骨髓ALDH亮细胞治疗肺纤维化的选择重点关注骨髓特性的变化

• 批准号: 20K08519
• 负责人: NAKASHIMA Taku
• 金额: $ 2.83万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K08519/
• 关键词: Aldehyde dehydrogenase; ALDH; 線維化; 細胞治療; 骨髄; 肺線維症; 酸化ストレス; 性差; aldehyde dehydrogenase; 骨髄幹細胞; 間質性肺炎

项目成果

Mesenchymal stem cells cultured in serum-free medium suppress murine bleomycin-induced pulmonary fibrosis by enhancing regulatory T cell induction

无血清培养基中培养的间充质干细胞通过增强调节性 T 细胞诱导来抑制小鼠博莱霉素诱导的肺纤维化

• 发表时间: 2021
• 作者: Kurokawa K;Harada N;Sasano H;Takagi H;Takei S;Nakamura A;Kamada K;Yoshida A;Kikuchi K;Takahashi K.;Takao S，Nakashima T，Masuda T，Namba M，Sakamoto S，Yamaguchi K，Horimasu Y，Miyamoto S，Iwamoto H， Fujitaka K，Hamada H，Nakashima A，Hattori N
• 通讯作者: Takao S，Nakashima T，Masuda T，Namba M，Sakamoto S，Yamaguchi K，Horimasu Y，Miyamoto S，Iwamoto H， Fujitaka K，Hamada H，Nakashima A，Hattori N

肺線維症マウスにおける骨髄性質の変化

肺纤维化小鼠骨髓特性的变化

• 发表时间: 2020
• 作者: Kabwe JC;Sawada H;Mitani Y;Oshita H;Tsuboya N;Zhang E;Maruyama J;Miyasaka Y;Ko H;Oya K;Ito H;Yodoya N;Otsuki S;Ohashi H;Okamoto R;Dohi K;Nishimura Y;Mashimo T;Hirayama M;Maruyama K.;中島 拓
• 通讯作者: 中島 拓

Prognostic Significance of EGFR Gene Mutation in Patients With EGFR Mutated Non-small Cell Lung Cancer Who Received Best Supportive Care Alone

• DOI: 10.21873/anticanres.15047
• 发表时间: 2021-05-01
• 期刊: ANTICANCER RESEARCH
• 影响因子: 2
• 作者: Masuda, Takeshi;Wakabayashi, Yu;Hattori, Noboru
• 通讯作者: Hattori, Noboru

EGFR gene mutation is not a significant risk factor in patients with EGFR mutated non-small cell lung cancer who receive best supportive care alone

对于仅接受最佳支持治疗的 EGFR 突变非小细胞肺癌患者，EGFR 基因突变不是显着危险因素

• 发表时间: 2020
• 作者: Masuda T;Wakabayashi Y;Shimoji K;Yamaguchi K;Sakamoto S;Nishimura Y;Horimasu Y;Nakashima T;Miyamoto S;Senoo T;Iwamoto H;Ohshimo S;Fujitaka K;Hamada H;Hattori N.
• 通讯作者: Hattori N.

Pre-existing interstitial lung abnormalities are risk factors for immune checkpoint inhibitor-induced interstitial lung disease in non-NSCLC cancers.

预先存在的间质性肺异常是非 NSCLC 癌症中免疫检查点抑制剂诱导的间质性肺疾病的危险因素。

• 发表时间: 2020
• 作者: Shimoji K;Masuda T;Nakanishi Y;Yamaguchi K;Sakamoto S;Horimasu Y;Nakashima T;Miyamoto S;Iwamoto H;Fujitaka K;Hamada H;Hattori N.
• 通讯作者: Hattori N.