GRK 2290: Crossing Boundaries: Molecular Interactions in Malaria

GRK 2290：跨越界限：疟疾中的分子相互作用

• 批准号: 313717432
• 金额: --
• 依托单位: Robert Koch-Institut (RKI)
• 依托单位国家: 德国
• 项目类别: International Research Training Groups
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/313717432?language=en
• 关键词: GRK; 2290; Crossing; Boundaries; Molecular

Malaria continues to be a major global threat to human health and the world’s economies. It is caused by five species of Plasmodium, arthropod-borne single-cell eukaryotic pathogens. Malaria is one of the most complex infectious diseases and many principles in disease dynamics and parasite-host crosstalk remain to be deciphered. Widespread tolerance against insecticides in the Anopheles vector population, the lack of an effective vaccine and observed resistance of the parasite against every approved antimalarial drug on the market instigates the need of innovative approaches and products to achieve sustained and large-scale malaria elimination. Molecular insights into Plasmodium infections can generate novel evidence-based strategies to develop curative and prophylactic drugs and create immunization strategies that elicit lasting protection. The Alliance Berlin-Canberra aspires to address fundamental problems in malaria through an international research training group (IRTG). The program covers four project areas, (A) Nutrient uptake and Metabolism, (B) Parasite Genetics and Adaptations, (C) Immune Responses, and (D) Host Genetics and Responses. Within these alliance researchers will have access to cultured Plasmodium falciparum parasites, the robust Plasmodium berghei murine malaria model, Plasmodium-infected Anopheles stephensi mosquitoes, clinical samples from infected patients, and heterologous expression systems. Performing cutting-edge malaria research in a truly global partnership will be a pivotal experience and prepare all graduate students to solve complex problems and navigate international collaborations. This graduate program is exceptional since all research projects will be jointly performed at two prominent malaria research institutions in Berlin and Canberra. Enrolled students will spend one year at the partner institution, thereby benefitting from the synergy, expertise and technology at both sites. IRTG students will graduate with dual affiliation from Humboldt-Universität zu Berlin and Australian National University. A customized training program will support the PhD students in acquiring critical skills to prepare them for increasingly globalized and competitive public and private job markets. Voluntary internships with non-academic partners and an innovative and continuous e-learning program will further promote an interconnected environment. Graduates will be independent, interdisciplinary, innovative researchers, who have substantially contributed to scientific knowledge and matured into sovereign intellectuals with profound analytical and problem-solving skills. The medical importance of malaria, research synergy, and international training program in two capital cities will act as a nucleus for future international collaboration and research networks.

疟疾仍然是对人类健康和世界经济的一个重大全球威胁。它是由五种疟原虫引起的，疟原虫是节肢动物传播的单细胞真核病原体。疟疾是最复杂的传染病之一，疾病动力学和寄生虫-宿主串扰的许多原理仍有待破译。由于按蚊病媒群体普遍对杀虫剂有耐受性，缺乏有效的疫苗，以及观察到寄生虫对市场上每一种经批准的抗疟药物都有抗药性，因此需要创新的方法和产品，以实现持续和大规模消灭疟疾。对疟原虫感染的分子见解可以产生新的循证策略，以开发治疗性和预防性药物，并创建可产生持久保护的免疫策略。柏林-堪培拉联盟希望通过一个国际研究培训小组解决疟疾的根本问题。该计划涵盖四个项目领域，（A）营养吸收和代谢，（B）寄生虫遗传学和适应，（C）免疫反应，（D）宿主遗传学和反应。在这些联盟中，研究人员将有机会获得培养的恶性疟原虫寄生虫，强大的伯氏疟原虫鼠疟疾模型，疟原虫感染的斯氏按蚊蚊子，感染患者的临床样本和异源表达系统。在真正的全球伙伴关系中进行尖端的疟疾研究将是一个关键的经验，并准备所有研究生解决复杂的问题和导航国际合作。这个研究生课程是特殊的，因为所有的研究项目将在柏林和堪培拉的两个著名的疟疾研究机构联合进行。入学的学生将在合作机构度过一年，从而受益于两个地点的协同作用，专业知识和技术。IRTG学生将毕业于柏林洪堡大学和澳大利亚国立大学的双重附属机构。一个定制的培训计划将支持博士生获得关键技能，使他们为日益全球化和竞争激烈的公共和私人就业市场做好准备。与非学术合作伙伴的自愿实习以及创新和持续的电子学习计划将进一步促进相互联系的环境。毕业生将是独立的，跨学科的，创新的研究人员，他们对科学知识做出了重大贡献，并成熟为具有深刻分析和解决问题能力的主权知识分子。疟疾的医学重要性、研究协同作用以及两个首都城市的国际培训计划将成为未来国际合作和研究网络的核心。