FOR 832: Regulators of the Humoral Immune Response

FOR 832：体液免疫反应的调节剂

• 批准号: 31394370
• 金额: --
• 依托单位: L f Genetik - AG Thomas Winkler
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2007
• 资助国家: 德国
• 起止时间: 2006-12-31 至 2015-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/31394370?language=en
• 关键词: 832; Regulators; Humoral; Immune; Response

Since the discovery of the antibody-mediated (humoral) immune response more than 100 years ago, the structure of antibody molecules, the mechanisms for the generation of antibody diversity and for the secretion of antibodies have been elucidated. The regulation of the humoral immune response is not yet understood, however. In particular, the processes involved in the selection of the primary antibody repertoire and the negative selection of autoreactive B-lymphocytes, the intracellular signalling cascades during an immune response, the interaction of B-lymphocytes with other immune cells and the regulation of the lifespan of the plasma cells are only poorly understood. Therefore, this Research Unit is analysing the "Regulators of the humoral immune response".

自从100多年前发现抗体介导的（体液）免疫应答以来，抗体分子的结构、抗体多样性的产生机制和抗体分泌机制已经被阐明。然而，体液免疫应答的调节还不清楚。特别是，涉及一抗库的选择和自身反应性B淋巴细胞的阴性选择、免疫应答期间的细胞内信号传导级联、B淋巴细胞与其他免疫细胞的相互作用以及浆细胞寿命的调节的过程仅知之甚少。因此，本研究股正在分析“体液免疫反应调节剂”。