SOLAR III: Asthma and allergies from school age up to working life - analyses of occupational exposures and transgenerational effects over three generations.20-years Follow-up of the ISAAC Phase II Study in Germany.

SOLAR III：从学龄到工作生活的哮喘和过敏 - 对三代人的职业暴露和跨代影响的分析。德国 ISAAC 第二阶段研究的 20 年随访。

• 批准号: 314488639
• 负责人: Professorin Dr. Katja Radon
• 金额: --
• 依托单位: Klinik und Poliklinik für Kinder- und Jugendmedizin
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/314488639?language=en
• 关键词: SOLAR; III; Asthma; allergies; age

The Study on Occupational Allergy Risks (SOLAR) is a population-based, prospective cohort study on asthma and allergies focussing on the impact of occupational exposures. This study was conducted in the participants of Phase II of the International Study of Asthma and Allergies in Childhood (ISAAC), which in 1995/1996 initially examined elementary school children (9-11 years) in the German cities of Munich and Dresden, among others. This baseline study was succeeded in 2002-03 and 2007-2009 by the 1st and 2nd follow-up SOLAR I und SOLAR II; the participants of this cohort form the G1 generation for the continuation of the study suggested here. The course of asthma and allergies since elementary school was assessed longitudinally in these participants. Information on prenatal risk factors are available for their parents (G0 generation) as well. Since 2009, the children (G2 generation) of the SOLAR II participants are being recruited in a birth cohort study (ACROSSOLAR). Following the participants of the G1 generation until their 4th decade of life, as well as their partners (G1) and their parents (G0) and children (G2), the course of asthma and allergies shall be described across three generations. The influence of occupational as well as environmental exposures will be examined in particular, taking into account epigenetic effects. To achieve these aims, the 3rd follow-up of the G1 generation (aged 30-32 years) and the 1st follow-up of the G2 generation (aged 6-11 years) shall be conducted with the presented proposal. All of the 2.051 SOLAR II participants will be invited to complete a paper questionnaire on work history, environmental exposures and asthma as well as allergies. The 125 participants of the G2 generation and their parents will be surveyed by questionnaire as well; moreover, clinical examinations will be offered to them. Allergy testing, lung function testing and bronchial challenge testing will be performed in the G2 generation, while genome-wide methylation in CD4+ T cells will be examined in the G1 and G2 generations. The results of this investigation will contribute to the comprehension of the longitudinal course of atopic diseases under special consideration of occupational exosures. The inclusion of three generations facilitates a better understanding of epigenetic effects and hence the genesis of atopic diseases. Thus, these studies will be conducive to the prevention of these diseases in the long term.

职业性过敏风险研究（SOLAR）是一项以人群为基础的前瞻性队列研究，重点关注职业暴露对哮喘和过敏的影响。这项研究是在儿童哮喘和过敏症国际研究（ISAAC）第二阶段的参与者中进行的，该研究于1995/1996年首次对德国慕尼黑和德累斯顿等城市的小学儿童（9-11岁）进行了调查。该基线研究在2002-03年和2007-2009年的第1次和第2次随访SOLAR I和SOLAR II中获得成功;该队列的参与者形成了G1代，以继续进行此处建议的研究。对这些参与者从小学开始的哮喘和过敏过程进行了纵向评估。关于产前风险因素的信息也提供给他们的父母（G 0代）。自2009年以来，SOLAR II参与者的儿童（G2代）正在招募出生队列研究（ACROSSOLAR）。跟踪G1代受试者直至其40岁，以及他们的伴侣（G1）、父母（G 0）和子女（G2），应跨三代描述哮喘和过敏的病程。将特别审查职业和环境暴露的影响，同时考虑到表观遗传效应。为了实现这些目标，应使用所提交的提案对G1代（30-32岁）进行第3次随访，对G2代（6-11岁）进行第1次随访。所有2.051名SOLAR II参与者将被邀请完成一份关于工作史、环境暴露、哮喘和过敏的纸质问卷。125名G2代参与者及其父母也将接受问卷调查;此外，还将为他们提供临床检查。过敏试验、肺功能试验和支气管激发试验将在G2代中进行，而CD 4 + T细胞的全基因组甲基化将在G1和G2代中进行检查。本研究的结果将有助于理解特应性疾病的纵向过程中特别考虑职业暴露。包括三代有利于更好地理解表观遗传效应，因此特应性疾病的起源。因此，这些研究将有助于长期预防这些疾病。