Structural flexibility in the Hepatitis C virus glycoprotein complex as viral strategy to evade the humoral immune system (B10)

丙型肝炎病毒糖蛋白复合物的结构灵活性作为病毒逃避体液免疫系统的策略 (B10)

• 批准号: 314569734
• 金额: --
• 依托单位: Institut für Biochemie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/314569734?language=en
• 关键词: Structural; flexibility; Hepatitis; virus; glycoprotein

The majority of hepatitis C virus (HCV) infected patients fails to clear the virus during the acute phase and conformational flexibility in the glycoprotein E2 was proposed to serve as mechanism to evade from neutralizing antibodies. In this project, we aim to determine the 3D structure of the conformationally flexible epitopes targeted by neutralizing antibodies in the context of the native glycoprotein complex. Furthermore, we will characterize the antibody response of HCV infected patients to these conformationally flexible epitopes.

大多数丙型肝炎病毒（HCV）感染的患者在急性期未能清除病毒，糖蛋白E2的构象灵活性被认为是逃避中和抗体的机制。在这个项目中，我们的目标是确定三维结构的构象灵活的表位的中和抗体的背景下，天然糖蛋白复合物。此外，我们将描述HCV感染患者对这些构象灵活的表位的抗体应答。