Deep learning on genome sequence to identify epistatic effects in complex diseases
Deep learning on genome sequence to identify epistatic effects in complex diseases
基因组序列深度学习可识别复杂疾病的上位效应
批准号：
20K15773
负责人：
Koido Masaru
金额：
$2.66万
依托单位：
依托单位国家：
日本
项目类别：
Grant-in-Aid for Early-Career Scientists
财政年份：
2020
资助国家：
日本
项目状态：
已结题
起止时间：
2020-04-01 至 2023-03-31
中文摘要
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英文摘要
期刊论文(16)
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DOI：
10.1038/s41586-022-05165-3
发表时间：
2022-11
期刊：
NATURE
影响因子：
64.8
作者：
[Mishra, Aniket, Malik, Rainer, Hachiya, Tsuyoshi, Jurgenson, Tuuli, Namba, Shinichi, Posner, Daniel C., Kamanu, Frederick K., Koido, Masaru, Le Grand, Quentin, Shi, Mingyang, He, Yunye, Georgakis, Marios K., Caro, Ilana, Krebs, Kristi, Liaw, Yi-Ching, Vaura, Felix C., Lin, Kuang, Winsvold, Bendik Slagsvold, Srinivasasainagendra, Vinodh, Parodi, Livia, Bae, Hee-Joon, Chauhan, Ganesh, Chong, Michael R., Tomppo, Liisa, Akinyemi, Rufus, Roshchupkin, Gennady V., Habib, Naomi, Jee, Yon Ho, Thomassen, Jesper Qvist, Abedi, Vida, Carcel-Marquez, Jara, Nygaard, Marianne, Leonard, Hampton L., Yang, Chaojie, Yonova-Doing, Ekaterina, Knol, Maria J., Lewis, Adam J., Judy, Renae L., Ago, Tetsuro, Amouyel, Philippe, Armstrong, Nicole D., Bakker, Mark K., Bartz, Traci M., Bennett, David A., Bis, Joshua C., Bordes, Constance, Borte, Sigrid, Cain, Anael, Ridker, Paul M., Cho, Kelly, Chen, Zhengming, Cruchaga, Carlos, Cole, John W., de Jager, Phil L., de Cid, Rafael, Endres, Matthias, Ferreira, Leslie E., Geerlings, Mirjam I., Gasca, Natalie C., Gudnason, Vilmundur, Hata, Jun, He, Jing, Heath, Alicia K., Ho, Yuk-Lam, Havulinna, Aki S., Hopewell, Jemma C., Hyacinth, Hyacinth I., Inouye, Michael, Jacob, Mina A., Jeon, Christina E., Jern, Christina, Kamouchi, Masahiro, Keene, Keith L., Kitazono, Takanari, Kittner, Steven J., Konuma, Takahiro, Kumar, Amit, Lacaze, Paul, Launer, Lenore J., Lee, Keon-Joo, Lepik, Kaido, Li, Jiang, Li, Liming, Manichaikul, Ani, Markus, Hugh S., Marston, Nicholas A., Meitinger, Thomas, Mitchell, Braxton D., Montellano, Felipe A., Morisaki, Takayuki, Mosley, Thomas H., Nalls, Mike A., Nordestgaard, Borge G., O'Donnell, Martin J., Okada, Yukinori, Onland-Moret, N. Charlotte, Ovbiagele, Bruce, Peters, Annette, Psaty, Bruce M., Rich, Stephen S., Rosand, Jonathan, Sabatine, Marc S., Sacco, Ralph L., Saleheen, Danish, Sandset, Else Charlotte, Salomaa, Veikko, Sargurupremraj, Muralidharan, Sasaki, Makoto, Satizabal, Claudia L., Schmidt, Carsten O., Shimizu, Atsushi, Smith, Nicholas L., Sloane, Kelly L., Sutoh, Yoichi, Sun, Yan V., Tanno, Kozo, Tiedt, Steffen, Tatlisumak, Turgut, Torres-Aguila, Nuria P., Tiwari, Hemant K., Tregouet, David-Alexandre, Trompet, Stella, Tuladhar, Anil Man, Tybjaerg-Hansen, Anne, van Vugt, Marion, Vibo, Riina, Verma, Shefali S., Wiggins, Kerri L., Wennberg, Patrik, Woo, Daniel, Wilson, Peter W. F., Xu, Huichun, Yang, Qiong, Yoon, Kyungheon, Millwood, Iona Y., Gieger, Christian, Ninomiya, Toshiharu, Grabe, Hans J., Jukema, J. Wouter, Rissanen, Ina L., Strbian, Daniel, Kim, Young Jin, Chen, Pei-Hsin, Mayerhofer, Ernst, Howson, Joanna M. M., Irvin, Marguerite R., Adams, Hieab, Wassertheil-Smoller, Sylvia, Christensen, Kaare, Ikram, Mohammad A., Rundek, Tatjana, Worrall, Bradford B., Lathrop, G. Mark, Riaz, Moeen, Simonsick, Eleanor M., Korv, Janika, Franca, Paulo H. C., Zand, Ramin, Prasad, Kameshwar, Frikke-Schmidt, Ruth, de Leeuw, Frank-Erik, Liman, Thomas, Haeusler, Karl Georg, Ruigrok, Ynte M., Heuschmann, Peter Ulrich, Longstreth, W. T., Jung, Keum Ji, Bastarache, Lisa, Pare, Guillaume, Damrauer, Scott M., Chasman, Daniel I., Rotter, Jerome I., Anderson, Christopher D., Zwart, John-Anker, Niiranen, Teemu J., Fornage, Myriam, Liaw, Yung-Po, Seshadri, Sudha, Fernandez-Cadenas, Israel, Walters, Robin G., Ruff, Christian T., Owolabi, Mayowa O., Huffman, Jennifer E., Milani, Lili, Kamatani, Yoichiro, Dichgans, Martin, Debette, Stephanie, Lee, Jin-Moo, Cheng, Yu-Ching, Meschia, James F., Chen, Wei Min, Sale, Michele M., Zonderman, Alan B., Evans, Michele K., Wilson, James G., Correa, Adolfo, Traylor, Matthew, Lewis, Cathryn M., Reiner, Alexander, Haessler, Jeffrey, Langefeld, Carl D., Gottesman, Rebecca F., Yaffe, Kristine, Liu, Yong Mei, Kooperberg, Charles, Lange, Leslie A., Furie, Karen L., Arnett, Donna K., Benavente, Oscar R., Grewal, Raji P., Peddareddygari, Leema Reddy, Hveem, Kristian, Lindstrom, Sara, Wang, Lu, Smith, Erin N., Gordon, William, Vlieg, Astrid van Hylckama, de Andrade, Mariza, Brody, Jennifer A., Pattee, Jack W., Brumpton, Ben M., Suchon, Pierre, Chen, Ming-Huei, Frazer, Kelly A., Turman, Constance, Germain, Marine, MacDonald, James, Braekkan, Sigrid K., Armasu, Sebastian M., Pankratz, Nathan, Jackson, Rebecca D., Nielsen, Jonas B., Giulianin, Franco, Puurunen, Marja K., Ibrahim, Manal, Heckbert, Susan R., Bammler, Theo K., McCauley, Bryan M., Taylor, Kent D., Pankow, James S., Reiner, Alexander P., Gabrielsen, Maiken E., Deleuze, Jean-Francois, O'Donnell, Chris J., Kim, Jihye, McKnight, Barbara, Kraft, Peter, Hansen, John-Bjarne, Rosendaal, Frits R., Heit, John A., Tang, Weihong, Morange, Pierre-Emmanuel, Johnson, Andrew D., Kabrhel, Christopher, van Dijk, Ewoud J., Koudstaal, Peter J., Luijckx, Gert-Jan, Nederkoorn, Paul J., van Oostenbrugge, Robert J., Visser, Marieke C., Wermer, Marieke J. H., Kappelle, L. Jaap, Esko, Tonu, Metspalu, Andres, Magi, Reedik, Nelis, Mari, Levi, Christopher R., Maguire, Jane, Jimenez-Conde, Jordi, Sharma, Pankaj, Sudlow, Cathie L. M., Rannikmae, Kristiina, Schmidt, Reinhold, Slowik, Agnieszka, Pera, Joanna, Thijs, Vincent N. S., Lindgren, Arne G., Ilinca, Andreea, Melander, Olle, Engstrom, Gunnar, Rexrode, Kathryn M., Rothwell, Peter M., Stanne, Tara M., Johnson, Julie A., Danesh, John, Butterworth, Adam S., Heitsch, Laura, Boncoraglio, Giorgio B., Kubo, Michiaki, Pezzini, Alessandro, Rolfs, Arndt, Giese, Anne-Katrin, Weir, David, Ross, Owen A., Lemmons, Robin, Soderholm, Martin, Cushman, Mary, Jood, Katarina, McDonough, Caitrin W., Bell, Steven, Linkohr, Birgit, Lee, Tsong-Hai, Putaala, Jukka, Lopez, Oscar L., Carty, Cara L., Jian, Xueqiu, Schminke, Ulf, Cullell, Natalia, Delgado, Pilar, Ibanez, Laura, Krupinski, Jerzy, Lioutas, Vasileios, Matsuda, Koichi, Montaner, Joan, Muino, Elena, Roquer, Jaume, Sarnowski, Chloe, Sattar, Naveed, Sibolt, Gerli, Teumer, Alexander, Rutten-Jacobs, Loes, Kanai, Masahiro, Gretarsdottir, Solveig, Rost, Natalia S., Yusuf, Salim, Almgren, Peter, Ay, Hakan, Bevan, Steve, Brown, Robert D., Jr., Carrera, Caty, Buring, Julie E., Chen, Wei-Min, Cotlarciuc, Ioana, de Bakker, Paul I. W., DeStefano, Anita L., den Hoed, Marcel, Duan, Qing, Engelter, Stefan T., Falcone, Guido J., Gustafsson, Stefan, Hassan, Ahamad, Holliday, Elizabeth G., Howard, George, Hsu, Fang-Chi, Ingelsson, Erik, Harris, Tamara B., Kissela, Brett M., Kleindorfer, Dawn O., Langenberg, Claudia, Leys, Didier, Lin, Wei-Yu, Lorentzen, Erik, Magnusson, Patrik K., McArdle, Patrick F., Pulit, Sara L., Rice, Kenneth, Sakaue, Saori, Sapkota, Bishwa R., Tanislav, Christian, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tzourio, Christophe, van Duijn, Cornelia M., Walters, Matthew, Wareham, Nicholas J., Amin, Najaf, Aparicio, Hugo J., Attia, John, Beiser, Alexa S., Berr, Claudine, Bustamante, Mariana, Caso, Valeria, Choi, Seung Hoan, Chowhan, Ayesha, Dartigues, Jean-Francois, Delavaran, Hossein, Dorr, Marcus, Ford, Ian, Gurpreet, Wander S., Hamsten, Anders, Hozawa, Atsushi, Ingelsson, Martin, Iwasaki, Motoki, Kaffashian, Sara, Kalra, Lalit, Kjartansson, Olafur, Kloss, Manja, Labovitz, Daniel L., Laurie, Cathy C., Li, Linxin, Lind, Lars, Lindgren, Cecilia M., Makoto, Hirata, Minegishi, Naoko, Morris, Andrew P., Mueller-Nurasyid, Martina, Norrving, Bo, Ogishima, Soichi, Parati, Eugenio A., Pedersen, Nancy L., Perola, Markus, Jousilahti, Pekka, Pileggi, Silvana, Rabionet, Raquel, Riba-Llena, Iolanda, Ribases, Marta, Romero, Jose R., Rudd, Anthony G., Sarin, Antti-Pekka, Sarju, Ralhan, Satoh, Mamoru, Sawada, Norie, Sigurdsson, Asgeir, Smith, Albert, Stine, O. Colin, Stott, David J., Strauch, Konstantin, Takai, Takako, Tanaka, Hideo, Touze, Emmanuel, Tsugane, Shoichiro, Uitterlinden, Andre G., Valdimarsson, Einar M., van der Lee, Sven J., Wakai, Kenji, Williams, Stephen R., Wolfe, Charles D. A., Wong, Quenna, Yamaji, Taiki, Sanghera, Dharambir K., Stefansson, Kari, Martinez-Majander, Nicolas, Sobue, Kenji, Soriano-Tarraga, Carolina, Volzke, Henry, Akpa, Onoja, Sarfo, Fred S., Akpalu, Albert, Obiako, Reginald, Wahab, Kolawole, Osaigbovo, Godwin, Owolabi, Lukman, Komolafe, Morenikeji, Jenkins, Carolyn, Arulogun, Oyedunni, Ogbole, Godwin, Adeoye, Abiodun M., Akinyemi, Joshua, Agunloye, Atinuke, Fakunle, Adekunle G., Uvere, Ezinne, Olalere, Abimbola, Adebajo, Olayinka J., Chen, Junshi, Clarke, Robert, Collins, Rory, Guo, Yu, Wang, Chen, Lv, Jun, Peto, Richard, Chen, Yiping, Fairhurst-Hunter, Zammy, Hill, Michael, Pozarickij, Alfred, Schmidt, Dan, Stevens, Becky, Turnbull, Iain, Yu, Canqing, Nagai, Akiko, Murakami, Yoishinori, Shiroma, Eric J., Sigurdsson, Sigurdur, Ghanbari, Mohsen, Boerwinkle, Eric, Fongang, Bernard, Wang, Ruiqi, Ikram, Mohammad K., Volker, Uwe, de Laat, Karlijn F., van Norden, Anouk G. W., de Kort, Paul L., Vermeer, Sarah E., Brouwers, Paul J. A. M., Gons, Rob A. R., den Heijer, Tom, van Dijk, Gert W., van Rooij, Frank G. W., Aamodt, Anne H., Skogholt, Anne H., Willer, Cristen J., Heuch, Ingrid, Hagen, Knut, Fritsche, Lars G., Pedersen, Linda M., Ellekjaer, Hanne, Zhou, Wei, Martinsen, Amy E., Kristoffersen, Espen S., Thomas, Laurent F., Kleinschnitz, Christoph, Frantz, Stefan, Ungethum, Kathrin, Gallego-Fabrega, Cristina, Lledos, Miquel, Llucia-Carol, Laia, Sobrino, Tomas, Campos, Francisco, Castillo, Jose, Freijo, Marimar, Arenillas, Juan Francisco, Obach, Victor, Alvarez-Sabin, Jose, Molina, Carlos A., Ribo, Marc, Munoz-Narbona, Lucia, Lopez-Cancio, Elena, Millan, Monica, Diaz-Navarro, Rosa, Vives-Bauza, Cristofol, Serrano-Heras, Gemma, Segura, Tomas, Dhar, Rajat, Delgado-Mederos, Raquel, Prats-Sanchez, Luis, Camps-Renom, Pol, Blay, Natalia, Sumoy, Lauro, Marti-Fabregas, Joan, Schnohr, Peter, Jensen, Gorm B., Benn, Marianne, Afzal, Shoaib, Kamstrup, Pia R., van Setten, Jessica, van der Laan, Sander W., Vonk, Jet M. J., Kim, Bong-Jo, Curtze, Sami, Tiainen, Marjaana, Kinnunen, Janne, Menon, Vilas, Sung, Yun Ju, Yang, Chengran, Saillour-Glenisson, Florence, Gravel, Simon]
通讯作者：
Gravel, Simon
DOI：
10.1101/2020.03.29.011205
发表时间：
2020-03
期刊：
bioRxiv
影响因子：
--
作者：
[Masaru Koido;C. Hon;S. Koyama;H. Kawaji;Y. Murakawa;K. Ishigaki;K. Ito;J. Sese;Y. Kamatani;Piero Carninci;C. Terao]
通讯作者：
Masaru Koido;C. Hon;S. Koyama;H. Kawaji;Y. Murakawa;K. Ishigaki;K. Ito;J. Sese;Y. Kamatani;Piero Carninci;C. Terao
遺伝的リスクを生物学的に解釈するゲノム・オミックス・ヒト細胞モデルの統合解析
基因组、组学和人类细胞模型的综合分析，从生物学角度解释遗传风险
基因组、组学和人类细胞模型的综合分析，从生物学角度解释遗传风险
DOI：
--
发表时间：
2022
期刊：
影响因子：
--
作者：
[Kamikawa R, Mochizuki T, Sakamoto M, Tanizawa Y, Nakayama T, Onuma R, Cenci U, Moog D, Speak S, Sarkozi K, Toseland A, van Oosterhout C, Oyama K, Kato M, Kume K, Kayama M, Azuma T, Ishii K, Miyashita H, Henrissat B, Lombard V, Win J, Kamoun S, Kashiyama Y, Mayama S, Miyagishima S, 小井土大]
通讯作者：
小井土大
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METR 发布工具
DOI：
--
发表时间：
期刊：
影响因子：
--
作者：
[]
通讯作者：
Stroke genetics informs drug discovery and risk prediction across ancestries
中风遗传学为跨血统的药物发现和风险预测提供信息
中风遗传学为跨血统的药物发现和风险预测提供信息
DOI：
10.21203/rs.3.rs-1175817/v1
发表时间：
2022
期刊：
Research Square
影响因子：
--
作者：
[Debette Stephanie, Mishra Aniket, Malik Rainer, Hachiya Tsuyoshi, Jurgenson Tuuli, Namba Shinichi, Koido Masaru, et al.]
通讯作者：
et al.
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