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脳血管造影とMRIの融合画像を用いた穿通枝領域の脳梗塞の病態解明

利用脑血管造影和 MRI 融合图像阐明穿支区脑梗死的病理学

基本信息

批准号：
20K16716
负责人：
高下純平
金额：
$ 2.75万
依托单位：
National Cardiovascular Center Research Institute
依托单位国家：
日本
项目类别：
Grant-in-Aid for Early-Career Scientists
财政年份：
2020
资助国家：
日本
起止时间：
2020-04-01 至 2024-03-31
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K16716/
关键词：
穿通枝梗塞脳血管造影 MRI 融合画像脳梗塞穿通枝

项目摘要

脳皮質下, 脳幹など脳血管の穿通枝領域の梗塞のうち, Branch atheromatous diseaseは, 進行性かつ重度の後遺症を生じ得る重要な病型である. しかし, 従来のMRIでは, 細径の穿通枝や近傍の動脈硬化性病変を描出することが困難なため, その病態は病理所見から提唱された概念の域を出ていない. 本研究は, 脳の穿通枝血管を描出可能な脳血管造影による3D rotational angiography画像と, MRI画像を融合するシステムを開発し, 穿通枝領域の脳梗塞の病態解明に資する情報の確率を目的とした研究である. 2020年度は, 穿通枝領域に梗塞を有する症例を集積, データベースを作成した. また, 研究支援目的の画像解析システム開発の経験を持つ, マックスネット社が制作したソフトウェア上で, 脳血管造影画像とMRI画像の位置合わせを可能にするアプリケーションを開発した. これにより, 穿通枝梗塞の融合画像から得られた穿通枝血管近傍の動脈硬化や穿通枝自体の形態の解析が可能となった. また, 位置合わせアプリケーションを用いて, 位置合わせの正確性検証のための位置合わせ実験の手法を確立し, これにより融合画像の位置合わせの誤差を定量化可能となった. 穿通枝領域単独の脳梗塞23例について, 融合画像作成および解析を行い, 11例で脳梗塞の責任穿通枝血管を同定可能であった. この研究成果を第46回日本脳卒中学会学術集会で口演発表した. また, 穿通枝領域に梗塞を有する118例の脳梗塞患者の解析を進めており, European Stroke Organization Conference 2023で発表予定である. 同内容の論文発表を準備中である.

Under the skin, the blood vessels penetrate the branches and infarct in the field of infarct, Branch atheromatous disease. The progressive severe sequelae can lead to important disease types. Please tell me how to MRI, how to get through the branch, and how to draw a picture of a sclerotic disease near the side of the tree. In this study, the perforating branch vessels may be depicted by angiography and 3D rotational angiography portraits, and the MRI portraits will be fused with each other. In this study, the perforating branch can be used to explain the state of infarction in the field of perforating branches. In the year 2020, a collection of cases of infarct infarction in the field of perforating branches were collected. Research support purpose: to analyze the picture, to make the picture, to make the picture, to show the location of the MRI portrait, and to make sure that the location of the image on the angiogram will match. The fusion portrait of the perforating branch infarction, the fusion portrait of the perforating branch infarction, the fusion portrait of the perforating branch infarction, the fusion portrait of the perforating branch infarction, the fusion portrait of the perforating branch infarction, the fusion portrait of the perforating branch infarction, the fusion portrait of the perforating branch infarction, the fusion portrait of the perforating branch infarction, the fusion portrait of the perforating branch infarction, the fusion portrait of the perforating branch infarction, the fusion portrait of the perforating branch infarction. The position is correct, the fusion portrait is correct, the position is correct, the fusion portrait is fixed, and In 23 cases of perforating branch infarction, the fusion portrait was made into an analytical line, and in 11 cases, the perforating branch vessels were identified as possible. The 46th round of research results will be presented orally at the Stroke Society academic gathering in Japan. A total of 118 patients with acute myocardial infarction were analyzed and predicted by European Stroke Organization Conference 2023. The same content is in the preparation of the article table.