Effect of Enamel Matrix Derivative on Avulsed Tooth Treatment

去年我用移植的方法进行了体内动物实验，观察牙釉质基质衍生物emdogain（EMD）对牙周组织的影响。强直是由牛奶引起的牙周膜（PDL）紊乱引起的。将EMD应用于牙根表面并皮下植入。应用 EMD 后，PDL 中 CD68 阳性细胞和组织蛋白酶-K 阳性细胞的数量减少。 PDL 抑制上皮细胞增殖和生长，这是 EMD 促进牙周组织再生的关键特征。 EMD组比牛奶浸泡1h组有更多的牙槽骨形成。这表明PDL促进成纤维细胞增殖和生长并抑制上皮细胞增殖和生长。我的一些新研究数据在国际会议上发表。

I conducted in vivo animal experiments using a transplantation method to observe the effects of enamel matrix derivative emdogain (EMD) on periodontal tissue last year. Ankylosis is caused by disturbance of the periodontal ligament (PDL) caused by milk. The EMD was applied to the tooth root surface and subcutaneously implanted. There was a reduction in the number of CD68-positive cells and cathepsin-K positive cells in the PDL after the application of the EMD. PDL inhibits epithelial cell proliferation and growth which is a key feature of EMD that promotes regeneration of periodontal tissues. The EMD group had more alveolar bone formation than the 1h immersion in the milk group. This suggests that PDL promotes fibroblast proliferation and growth and inhibits epithelial cell proliferation and growth. Some of my new research data were presented at international conferences.