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Effect of Enamel Matrix Derivative on Avulsed Tooth Treatment

牙釉质基质衍生物对牙齿撕脱治疗的效果

基本信息

批准号：
20K18541
负责人：
Hasan MdRiasat
金额：
$ 2.66万
依托单位：
Health Sciences University of Hokkaido
依托单位国家：
日本
项目类别：
Grant-in-Aid for Early-Career Scientists
财政年份：
2020
资助国家：
日本
起止时间：
2020-04-01 至 2024-03-31
项目状态：
已结题

项目摘要

I conducted in vivo animal experiments using a transplantation method to observe the effects of enamel matrix derivative emdogain (EMD) on periodontal tissue last year. Ankylosis is caused by disturbance of the periodontal ligament (PDL) caused by milk. The EMD was applied to the tooth root surface and subcutaneously implanted. There was a reduction in the number of CD68-positive cells and cathepsin-K positive cells in the PDL after the application of the EMD. PDL inhibits epithelial cell proliferation and growth which is a key feature of EMD that promotes regeneration of periodontal tissues. The EMD group had more alveolar bone formation than the 1h immersion in the milk group. This suggests that PDL promotes fibroblast proliferation and growth and inhibits epithelial cell proliferation and growth. Some of my new research data were presented at international conferences.

去年，我用移植的方法进行了活体动物实验，观察了釉质基质衍生物Emdogain(EMD)对牙周组织的影响。强直是由牛奶引起的牙周膜(PDL)紊乱引起的。将EMD应用于牙根表面，皮下种植。应用EMD后，PDL中CD68阳性细胞和Cathepsin-K阳性细胞数明显减少。PDL抑制上皮细胞的增殖和生长，这是EMD促进牙周组织再生的关键特征。EMD组较牛奶组浸泡1h后牙槽骨形成明显增多。提示PDL促进成纤维细胞的增殖和生长，抑制上皮细胞的增殖和生长。我的一些新研究数据是在国际会议上公布的。