Effect of Enamel Matrix Derivative on Avulsed Tooth Treatment

我在去年进行了活体动物实验，采用移植方法观察了牙釉质基质衍生物emdogain（牙釉质基质衍生物emdogain， EMD）对牙周组织的影响。强直是由牛奶引起的牙周韧带（PDL）紊乱引起的。EMD应用于牙根表面，皮下植入。应用EMD后，PDL中cd68阳性细胞和cathepsink阳性细胞数量减少。PDL抑制上皮细胞的增殖和生长，这是EMD促进牙周组织再生的关键特征。EMD组的牙槽骨形成明显多于浸泡1h的牛奶组。提示PDL促进成纤维细胞增殖和生长，抑制上皮细胞增殖和生长。我的一些新研究数据在国际会议上发表过。

I conducted in vivo animal experiments using a transplantation method to observe the effects of enamel matrix derivative emdogain (EMD) on periodontal tissue last year. Ankylosis is caused by disturbance of the periodontal ligament (PDL) caused by milk. The EMD was applied to the tooth root surface and subcutaneously implanted. There was a reduction in the number of CD68-positive cells and cathepsin-K positive cells in the PDL after the application of the EMD. PDL inhibits epithelial cell proliferation and growth which is a key feature of EMD that promotes regeneration of periodontal tissues. The EMD group had more alveolar bone formation than the 1h immersion in the milk group. This suggests that PDL promotes fibroblast proliferation and growth and inhibits epithelial cell proliferation and growth. Some of my new research data were presented at international conferences.