Effect of antioxidans on the reduction of DNA toxicity caused by intermediates and eluates from commercially available and experimental dental restorative materials

抗氧化剂对降低市售和实验牙科修复材料中间体和洗脱物引起的 DNA 毒性的影响

• 批准号: 315677466
• 负责人: Professor Dr. Franz-Xaver Reichl
• 金额: --
• 依托单位: Poliklinik für Zahnerhaltung und Parodontologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/315677466?language=en
• 关键词: Effect; antioxidans; reduction; DNA; toxicity

Comonomers and monomers are used as dental restorative materials. Unconverted com-pounds can be released from dental composites and can enter the body in humans. The up-take, distribution, and excretion of (co)monomers have been elucidated in animal studies. In the metabolism of these (co)monomers the formation of toxic intermediates as epoxides were detected. Epoxy-compounds are regarded as toxic compounds and they can influence the redoxhomöstasis in the cells.Due to the potential reactivity of epoxides and their consecutive reactions, in this study the effect of antioxidans on the reduction of DNA damages caused by epoxides and (co)monomers eluted from commercially available and experimental composites should be examined in human cells. This research application represents a cooperation ap-plication. In all joint studies identical dental materials, identical cells and identical manufactur-ing processes for the production of e.g. eluates from dental materials are used.

共聚单体和单体用作牙科修复材料。未转化的化合物可以从牙科复合材料中释放出来，并可以进入人体。已在动物研究中阐明了（共聚）单体的摄取、分布和排泄。在这些（共）单体的代谢中，检测到形成有毒中间体作为环氧化物。环氧化合物被认为是有毒的化合物，它们可以影响细胞中的氧化还原稳态，由于环氧化合物的潜在反应性和它们的连续反应，在本研究中，抗氧化剂对减少由环氧化合物和（共）单体引起的DNA损伤的影响应在人细胞中进行检查。该研究应用是一个合作应用。在所有联合研究中，使用相同的牙科材料、相同的细胞和相同的生产工艺，例如从牙科材料中生产洗脱液。