骨格筋代謝機能に着目した加齢に伴う筋の質的変化の検討

检查因衰老引起的肌肉质变，重点关注骨骼肌代谢功能

• 批准号: 20K19691
• 负责人: 吉子 彰人
• 金额: $ 2.58万
• 依托单位: Chukyo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K19691/
• 关键词: 筋細胞内脂肪; 磁気共鳴分光装置; 筋代謝機能; 高齢者; 骨格筋代謝; 磁気共鳴分光法

本研究の目的は，骨格筋内の脂肪と筋の代謝指標 (筋酸素化機能) を異なる年齢間 (高齢者 vs. 若齢者) で比較し，さらに骨格筋内の脂肪と筋の代謝指標との関係を検討することであった．本年度は，若齢者28名，高齢者21名を用いて本実験を実施した．測定項目は，昨年度の予備実験の結果を考慮し，磁気共鳴分光装置を用いた腓腹筋内側頭における筋細胞内脂肪・筋細胞外脂肪，近赤外線分光装置を用いた同筋における筋酸素化機能，磁気共鳴画像装置を用いた同筋における筋横断面積，足関節最大底屈筋力，足関節底屈筋力の立ち上がり速度，足関節筋持久力とした．また高齢者においては，運動機能に関する値 (最大歩行速度，四肢の筋量指数，握力，Timed Up and Go) の測定を実施した．得られたデータを解析し，研究目的の解決に向けて検討した．筋細胞内脂肪は若齢者と比較し，高齢者において有意に低値が示された (5.0 ± 4.2 vs. 1.8 ± 1.0 mmol kg-1 wet weight)．一方，筋細胞外脂肪は高齢者において有意に高い値を示した (21.7 ± 11.0 vs. 198.8 ± 86.0 mmol kg-1 wet weight)．筋酸素化機能は両者間で有意な差を認めなかった．今後は目的の後半部分に当たる「各パラメータの関係性」についても検討する．また今回のデータの解析を進めていく上で新たな課題も見えてきた．高齢者における筋酸素化機能の生理学的意義については十分な検討が行われていないことに注目し，高齢者の筋酸素化機能と運動機能に関する値との関係性の検討を合わせて進めていく．

The purpose of this study was to investigate the relationship between metabolic indices of fat and tendon in bone cells and to compare them between years (high vs. low). This year, there were 28 outstanding candidates and 21 outstanding candidates. The measurement items were taken into account in the previous year's preliminary results. Magnetic resonance spectroscopy was used to determine the intracellular fat and extracellular fat of the tendon. Near infrared spectroscopy was used to determine the muscle acid conversion function. Magnetic resonance imaging was used to determine the cross-sectional area of the tendon. The maximum bending force of the foot joint. The vertical speed of the bending force of the foot joint. The endurance force of the foot joint tendon. The measurement of motor function (maximum walking speed, muscle mass index of limbs, grip strength, Timed Up and Go) was carried out. The goal of the study is to solve the problem. The intracellular fat in muscle cells was higher than that in muscle cells (5.0 ± 4.2 vs. 1.8 ± 1.0 mmol kg-1 wet weight). In one case, the extracellular fat content of muscle was higher than that of the control group (21.7 ± 11.0 vs. 198.8 ± 86.0 mmol kg-1 wet weight). The function of tendon acidification is to recognize the difference between the two. In the future, the second half of the goal will be discussed in the "Relationship between each category" section. The analysis of the current situation and the new problem are discussed. The physiological significance of the function of muscle acid in high altitude patients is discussed in detail. The relationship between muscle acid function and motor function in high altitude patients is discussed in detail.