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Development of a Method to Evaluate Health Effects of Heated tobacco product and Cigarette from Exposure, Inflammation and Effect Markers

开发一种根据暴露、炎症和效应标记评估加热烟草产品和卷烟对健康影响的方法

基本信息

批准号：
21H03389
负责人：
稲葉洋平
金额：
$ 11.07万
依托单位：
National Institute of Public Health
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2021
资助国家：
日本
起止时间：
2021-04-01 至 2025-03-31
项目状态：
未结题

项目摘要

「加熱式たばこ」は、日本で販売開始されて10年近くが経過し、日本人喫煙者の25%が使用するまでに普及している。しかし、使用期間も短く加熱式たばこに関する健康影響は、不明な点が多い。我々は、これまでに加熱式たばこの主流煙・副流煙の有害化学物質の成分分析を行い、さらに、加熱式たばこと紙巻たばこ喫煙者の尿試料から曝露マーカーとしてニコチン代謝物、たばこ特異的ニトロソアミン(発がん性物質)代謝物等の分析を行ってきた。そこで本研究はこれまでの研究をさらに発展させ、1. 曝露マーカー、2.炎症マーカー及び3.影響マーカーの3つの評価項目について成分分析を行い、たばこの健康影響評価法の開発を行う。今年度は、これまでの加熱式たばこの成分分析結果と紙巻たばこと加熱式たばこ喫煙者のバイオマーカーの分析結果を発展させ、喫煙者の3種類の評価項目の分析から、今後の日本人喫煙者の健康影響評価法を開発している。初年度は、尿中曝露マーカー(ニコチン代謝物、NNAL、VOCバイオマーカー (17成分)、PAHバイオマーカー (7成分))分析値と使用たばこ製品群(紙巻たばこ喫煙者、加熱式たばこ喫煙者、併用者、非喫煙者)における尿中曝露バイオマーカーの分析を行うために、研究体制の構築と倫理審査を並行して進めた。揮発性有機化合物(VOC)の尿中代謝産物(燃焼由来のベンゼン、1,3-ブタジエンなどガス成分の代謝物17成分)の分析法の確認、多環芳香族炭化水素類(PAH)の尿中代謝産物(燃焼由来のピレンなど粒子成分の代謝物7成分)の分析法の確立を行った。

At the beginning of the 10-year training program, 25% of the Japanese people have used the Canadian food market to popularize the health care market. During the period of use, there will be a lot of health information during the period of use, not knowing what to do. The main stream of chemical analysis is harmful chemicals, chemical composition analysis, chemical composition analysis, chemical analysis and so on. The purpose of this study is to conduct a study on this subject. Exposure, 2. Inflammation, inflammation, inflammation and inflammation. In order to improve the quality of the project, the component analysis method and the health image method are required to start the business. The results of the component analysis of this year's training program, the results of this year's training program, and the results of the analysis of the results of this year's annual and annual annual company. the results of this year's component analysis, the results of this year's and post-test data analysis, the results of this year's and post-test data analysis results, the results of this year's annual and secondary training program composition analysis, the results of this year's annual and secondary training program composition analysis, the results of this year's annual health analysis, and the results of this year's annual and secondary training program composition analysis, the results of this year's annual and annual annual analysis, the results of this year's annual and annual annual analysis, and the results of this year's annual and secondary training program, the results show that the results of this year's annual analysis, the results of this year's annual analysis, and the results of this year's annual analysis, and the results of this year's annual and annual In the beginning of the year, exposure in urine and urine (NNAL, VOC and so on) was analyzed in terms of the use of the drug group (ingredient 7). The research system is responsible for the management and development of the research system. Phenolic organic compounds (VOC) uric substitutes (incinerated phenotypic compounds, 1 maleic acid compounds 17 components), polyaromatic carbonized hydrocarbons (PAH) urinary substitutes (incinerated phenolic compounds 7 components) were confirmed by chemical analysis.