Role of mitochondrial dynamics in neuronal synapse and circuit remodelling (A07)

线粒体动力学在神经元突触和回路重塑中的作用（A07）

• 批准号: 318025243
• 金额: --
• 依托单位: Cluster of Excellence: Cellular Stress Responses in Aging-Associated Diseases
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/318025243?language=en
• 关键词: Role; mitochondrial; dynamics; neuronal; synapse

Dysfunctional mitochondrial dynamics play a central role in the development of several neurodegenerative disorders. While some of the basic processes controlling fission-fusion as well as movement of mitochondria have been revealed, our understanding of the mechanisms that ensure mitochondrial distribution across complex neuronal geometries and their role in neuronal plasticity are still rudimentary. In this project, we investigate how mitochondrial dynamics regulate the maintenance of specific neuronal circuits and how their becoming dysfunctional potentially contributes to maladaptive changes in neuronal connectivity which are linked to the onset of epileptic seizures.

线粒体动力学功能障碍在几种神经退行性疾病的发展中起着核心作用。虽然一些基本的过程控制裂变融合以及运动的线粒体已经被发现，我们的理解，确保线粒体分布在复杂的神经元几何形状和它们的作用，神经元可塑性的机制仍然是初步的。在这个项目中，我们研究了线粒体动力学如何调节特定神经元回路的维持，以及它们如何变得功能失调，可能导致神经元连接的适应不良变化，这些变化与癫痫发作有关。