Role of mitochondria in the regulation of intestinal epithelial cell death and inflammation (B05)

线粒体在肠上皮细胞死亡和炎症调节中的作用（B05）

• 批准号: 318033217
• 金额: --
• 依托单位: Cluster of Excellence: Cellular Stress Responses in Aging-Associated Diseases
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/318033217?language=en
• 关键词: Role; mitochondria; regulation; intestinal; epithelial

The project aims to study the role of mitochondria in the regulation of lipid metabolism focusing particularly in two tissues that are important for organismal lipid homeostasis, namely the intestinal epithelium and the adipose tissue. Using relevant genetic mouse models, we will experimentally dissect how different mitochondrial processes regulate lipid metabolism and control energy homeostasis in a tissue-specific manner and assess their effects at the level of the whole organism.

该项目旨在研究线粒体在脂质代谢调节中的作用，特别关注对机体脂质稳态重要的两种组织，即肠上皮和脂肪组织。使用相关的遗传小鼠模型，我们将通过实验剖析不同的线粒体过程如何以组织特异性的方式调节脂质代谢和控制能量稳态，并评估它们在整个生物体水平上的影响。