Enhancement of conventional chemotherapy by treatment with an alkalinizing agent

通过碱化剂治疗增强常规化疗

• 批准号: 19K16415
• 负责人: ANDO Hidenori
• 金额: $ 2.66万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K16415/
• 关键词: アルカリ化剤; 腫瘍内中性化; 尿pH; 重曹（NaHCO3）; クエン酸塩; ドキソルビシン; Doxil; 抗PD-1抗体; 腫瘍中性化; NaHCO3; CD8+ T細胞; IFN-gamma; 抗腫瘍効果; 重曹; 抗がん剤; 尿アルカリ化

项目成果

Enhanced therapeutic efficacy of liposomal weak-base anticancer drugs by daily oral administration of sodium bicarbonate.

每日口服碳酸氢钠可增强脂质体弱碱抗癌药物的疗效。

• 发表时间: 2019
• 作者: Tagami;M.;Ando;H.;Ikeda;A.;Eshima;K.;Huang;C.L.;Wada;H.;Ishida;T.
• 通讯作者: T.

Zagazig University(エジプト)

扎加齐格大学（埃及）

Increasing Tumor Extracellular pH by an Oral Alkalinizing Agent Improves Antitumor Responses of Anti-PD-1 Antibody: Implication of Relationships between Serum Bicarbonate Concentrations, Urinary pH, and Therapeutic Outcomes

• DOI: 10.1248/bpb.b21-00076
• 发表时间: 2021-06-01
• 期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN
• 影响因子: 2
• 作者: Ando, Hidenori;Emam, Sherif E.;Ishida, Tatsuhiro
• 通讯作者: Ishida, Tatsuhiro

Neutralization of Acidic Tumor Microenvironment (TME) with Daily Oral Dosing of Sodium Potassium Citrate (K/Na Citrate) Increases Therapeutic Effect of Anti-cancer Agent in Pancreatic Cancer Xenograft Mice Model

• DOI: 10.1248/bpb.b20-00825
• 发表时间: 2021-02-01
• 期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN
• 影响因子: 2
• 作者: Ando, Hidenori;Eshima, Kiyoshi;Ishida, Tatsuhiro
• 通讯作者: Ishida, Tatsuhiro