Immunological Mechanisms of Synergistic Anti-cancer Activities by Activation of TLR9 and STING

TLR9 和 STING 激活协同抗癌活性的免疫学机制

• 批准号: 19K16833
• 负责人: TEMIZOZ BURCU
• 金额: $ 2.5万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K16833/
• 关键词: TLR9; STING; Synergy; Antitumor; Combination; IL-12; synergy; anti-tumor immunity; c-di-AMP; K3 CpG; anti-tumor; cancer immunotherapy; Cancer Immunotherapy; anti-tumor agent; memory

项目成果

DMXAA derivatives as potential immunotherapeutics for autoinflammation.

DMXAA 衍生物作为自身炎症的潜在免疫治疗剂。

• 发表时间: 2020
• 作者: Temizoz;B.
• 通讯作者: B.

Combination and inducible adjuvants targeting nucleic acid sensors

• DOI: 10.1016/j.coph.2018.05.003
• 发表时间: 2018-08
• 期刊: Current Opinion in Pharmacology
• 影响因子: 4
• 作者: Burcu Temizoz;E. Kuroda;K. Ishii

Immunological mechanism of synergistic anti-cancer activities by activation of TLR9 and STING

TLR9和STING激活协同抗癌活性的免疫学机制

• 发表时间: 2019
• 作者: Temizoz;B.;Hioki;K.;Takayuki;S.;Kobari;S.;Jounai;N.;Kusakabe;Lee;MSJ.;T.;Coban;C.;Kuroda;E.;and Ishii;K. J
• 通讯作者: K. J