Identification of D-type cyclin gene abnormalities and development of novel therapeutic strategies in pediatric acute myeloid leukemia

小儿急性髓系白血病 D 型细胞周期蛋白基因异常的鉴定及新治疗策略的开发

• 批准号: 19K16832
• 负责人: Matsuo Hidemasa
• 金额: $ 2.66万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K16832/
• 关键词: 白血病; AML; 遺伝子異常; t(8;21); CCND2; CDK4/6; オートファジー; 急性骨髄性白血病; アポトーシス; 次世代シークエンス; 遺伝子変異; CCND

项目成果

Blast cells in acute megakaryoblastic leukaemia with Down syndrome are characterized by low CLEC12A expression

• DOI: 10.1111/bjh.17122
• 发表时间: 2020-10
• 期刊: British Journal of Haematology
• 影响因子: 6.5
• 作者: H. Matsuo;T. Wakita;H. Hiramatsu;K. Ohmori;K. Kodama;K. Nakatani;Yasuhiko Kamikubo;S. Iwamoto;T. Kondo;A. Takaori-Kondo;J. Takita;D. Tomizawa;T. Taga;S. Adachi

Development of a novel single cell sequencing method from blood smears and pathological specimens

开发一种新型血涂片和病理标本单细胞测序方法

• 发表时间: 2021
• 作者: Moe Higashitani;Hidemasa Matsuo;Yutarou Harata;Yuri Ito;Aina Inagami;Nana Ito;Norimitsu Uza;Masahiro Shiokawa;Masashi Kanai;Manabu Muto;Souichi Adachi
• 通讯作者: Souichi Adachi

The importance of pan-RUNX and CROX (Cluster Regulation of RUNX) therapeutic approach for gastrointestinal cancers.

泛 RUNX 和 CROX（RUNX 集群调节）治疗方法对胃肠道癌症的重要性。

• 发表时间: 2019
• 作者: 原田優太郎;松尾英将;東谷萌絵;中谷香菜;上久保靖彦;足立壯一;Hidemasa Matsuo,Kenichi Yoshida,Kana Nakatani,Yasuhiko Kamikubo,Daisuke Tomizawa,Takashi Taga,Nobutaka Kiyokawa,Seishi Ogawa,Manja Meggendorfer,Claudia Haferlach,Souichi Adachi;Taeko Kaburagi,Genki Yamato,Norio Shiba,Kenichi Yoshida,Yusuke Hara,Yuichi Shiraishi,Kentaro Ohki,Manabu Sotomatsu,Hirokazu Arakawa,Hidemasa Matsuo,Akira Shimada,Tomohiko Taki,Nobutaka Kiyokawa,Daisuke Tomizawa,Keizo Horibe,Satoru Miyano,Takashi Taga,Soui;Yusuke Hara,Tomohiko Taki,Genki Yamato,Kenichi Yoshida,Yusuke Shiozawa,Norio Shiba,Taeko Kaburagi,Yuichi Shiraishi,Kentaro Ohki,Machiko Kawamura,Manabu Sotomatsu,Hirokazu Arakawa,Hidemasa Matsuo,...,Souichi Adachi,Yasuhide Hayashi;Taeko Kaburagi,Genki Yamato,Norio Shiba,Kenichi Yoshida,Yusuke Hara,Yuichi Shiraishi,Kentaro Ohki,Manabu Sotomatsu,Hirokazu Arakawa,Hidemasa Matsuo,Akira Shimada,Tomohiko Taki,Nobutaka Kiyokawa,Daisuke Tomizawa,Keizo Horibe,Satoru Miyano,Souichi Adachi,Ta;Yusuke Hara,Tomohiko Taki,Genki Yamato,Kenichi Yoshida,Norio Shiba,Taeko Kaburagi,Yuichi Shiraishi,Kentaro Ohki,Machiko Kawamura,Manabu Sotomatsu,Hirokazu Arakawa,Hidemasa Matsuo,Akira Shimada,Nobutaka Kiyokawa,Daisuke Tomizawa,Takashi Taga,Keizo Horibe,S;Kana Nakatani,Hidemasa Matsuo,Yuki Morimoto,Yasuhiko Kamikubo,Souichi Adachi;Taeko Kaburagi,Genki Yamato,Norio Shiba,Kenichi Yoshida,Yusuke Hara,Yuichi Shiraishi,Kentaro Ohki,Manabu Sotomatsu,Hirokazu Arakawa,Hidemasa Matsuo,Akira Shimada,Tomohiko Taki,Nobutaka Kiyokawa,Daisuke Tomizawa,Keizo Horibe,Satoru Miyano,Souichi Adachi,Ta;松尾英将,吉田健一,中谷香菜,上久保靖彦,小川誠司,足立壯一;能浦三奈,森田剣,清瀬大樹,立田俊也,松尾英将,上久保靖彦,足立壯一;増田達哉,片岡竜貴,立田俊也,松尾英将,杉山弘,足立壯一,上久保靖彦;小林紫乃,佐々木亜沙美,沖中えり佳,武田佳那子,武田瑞穂,松尾英将,野口勇貴,杉山弘,足立壯一,上久保靖彦;沖中えり佳,小林紫乃,武田瑞穂,佐々木亜沙美,武田佳那子,松尾英将,足立壯一,上久保靖彦;武田瑞穂,沖中えり佳,小林紫乃,割石菜月,佐々木亜沙美,武田佳那子,松尾英将,杉山弘,足立壯一,上久保靖彦
• 通讯作者: 武田瑞穂,沖中えり佳,小林紫乃,割石菜月,佐々木亜沙美,武田佳那子,松尾英将,杉山弘,足立壯一,上久保靖彦

ddPCRを用いた小児APLの微小残存病変の解析：AML-P17付随研究

使用 ddPCR 分析儿科 APL 的微小残留病：AML-P17 伴随研究

• 发表时间: 2019
• 作者: 原田優太郎;松尾英将;東谷萌絵;中谷香菜;上久保靖彦;足立壯一;Hidemasa Matsuo,Kenichi Yoshida,Kana Nakatani,Yasuhiko Kamikubo,Daisuke Tomizawa,Takashi Taga,Nobutaka Kiyokawa,Seishi Ogawa,Manja Meggendorfer,Claudia Haferlach,Souichi Adachi;Taeko Kaburagi,Genki Yamato,Norio Shiba,Kenichi Yoshida,Yusuke Hara,Yuichi Shiraishi,Kentaro Ohki,Manabu Sotomatsu,Hirokazu Arakawa,Hidemasa Matsuo,Akira Shimada,Tomohiko Taki,Nobutaka Kiyokawa,Daisuke Tomizawa,Keizo Horibe,Satoru Miyano,Takashi Taga,Soui;Yusuke Hara,Tomohiko Taki,Genki Yamato,Kenichi Yoshida,Yusuke Shiozawa,Norio Shiba,Taeko Kaburagi,Yuichi Shiraishi,Kentaro Ohki,Machiko Kawamura,Manabu Sotomatsu,Hirokazu Arakawa,Hidemasa Matsuo,...,Souichi Adachi,Yasuhide Hayashi;Taeko Kaburagi,Genki Yamato,Norio Shiba,Kenichi Yoshida,Yusuke Hara,Yuichi Shiraishi,Kentaro Ohki,Manabu Sotomatsu,Hirokazu Arakawa,Hidemasa Matsuo,Akira Shimada,Tomohiko Taki,Nobutaka Kiyokawa,Daisuke Tomizawa,Keizo Horibe,Satoru Miyano,Souichi Adachi,Ta;Yusuke Hara,Tomohiko Taki,Genki Yamato,Kenichi Yoshida,Norio Shiba,Taeko Kaburagi,Yuichi Shiraishi,Kentaro Ohki,Machiko Kawamura,Manabu Sotomatsu,Hirokazu Arakawa,Hidemasa Matsuo,Akira Shimada,Nobutaka Kiyokawa,Daisuke Tomizawa,Takashi Taga,Keizo Horibe,S;Kana Nakatani,Hidemasa Matsuo,Yuki Morimoto,Yasuhiko Kamikubo,Souichi Adachi;Taeko Kaburagi,Genki Yamato,Norio Shiba,Kenichi Yoshida,Yusuke Hara,Yuichi Shiraishi,Kentaro Ohki,Manabu Sotomatsu,Hirokazu Arakawa,Hidemasa Matsuo,Akira Shimada,Tomohiko Taki,Nobutaka Kiyokawa,Daisuke Tomizawa,Keizo Horibe,Satoru Miyano,Souichi Adachi,Ta;松尾英将,吉田健一,中谷香菜,上久保靖彦,小川誠司,足立壯一;能浦三奈,森田剣,清瀬大樹,立田俊也,松尾英将,上久保靖彦,足立壯一;増田達哉,片岡竜貴,立田俊也,松尾英将,杉山弘,足立壯一,上久保靖彦;小林紫乃,佐々木亜沙美,沖中えり佳,武田佳那子,武田瑞穂,松尾英将,野口勇貴,杉山弘,足立壯一,上久保靖彦;沖中えり佳,小林紫乃,武田瑞穂,佐々木亜沙美,武田佳那子,松尾英将,足立壯一,上久保靖彦;武田瑞穂,沖中えり佳,小林紫乃,割石菜月,佐々木亜沙美,武田佳那子,松尾英将,杉山弘,足立壯一,上久保靖彦;割石菜月,田中直,川口展子,沖中えり佳,小林紫乃,佐々木亜沙美,武田瑞穂,武田佳那子,松尾英将,足立壯一,上久保靖彦;三上真充,沖中えり佳,大封智雄,金谷卓弥,小林紫乃,服部悦子,松井恭澄,松尾英将,杉山弘,足立壯一,上久保靖彦;立田俊也,古市華菜,増田達哉,窪田博仁,岩井篤,三上真充,服部悦子,松尾英将,杉山弘,足立壯一,上久保靖彦;中谷香菜,松尾英将,上久保靖彦,足立壯一;徳野治,松尾英将,上久保靖彦,藤井康友,足立壯一,杉本直三;松尾英将,湯坐有希,高橋浩之,富澤大輔,多賀崇,足立壯一
• 通讯作者: 松尾英将,湯坐有希,高橋浩之,富澤大輔,多賀崇,足立壯一

The combinatorial Histone Acetyltransferases (HATs) inhibition as a novel therapeutic strategy for KRAS enhanced cancers.

组合组蛋白乙酰转移酶 (HAT) 抑制作为 KRAS 增强癌症的新型治疗策略。

• 发表时间: 2019
• 作者: 原田優太郎;松尾英将;東谷萌絵;中谷香菜;上久保靖彦;足立壯一;Hidemasa Matsuo,Kenichi Yoshida,Kana Nakatani,Yasuhiko Kamikubo,Daisuke Tomizawa,Takashi Taga,Nobutaka Kiyokawa,Seishi Ogawa,Manja Meggendorfer,Claudia Haferlach,Souichi Adachi;Taeko Kaburagi,Genki Yamato,Norio Shiba,Kenichi Yoshida,Yusuke Hara,Yuichi Shiraishi,Kentaro Ohki,Manabu Sotomatsu,Hirokazu Arakawa,Hidemasa Matsuo,Akira Shimada,Tomohiko Taki,Nobutaka Kiyokawa,Daisuke Tomizawa,Keizo Horibe,Satoru Miyano,Takashi Taga,Soui;Yusuke Hara,Tomohiko Taki,Genki Yamato,Kenichi Yoshida,Yusuke Shiozawa,Norio Shiba,Taeko Kaburagi,Yuichi Shiraishi,Kentaro Ohki,Machiko Kawamura,Manabu Sotomatsu,Hirokazu Arakawa,Hidemasa Matsuo,...,Souichi Adachi,Yasuhide Hayashi;Taeko Kaburagi,Genki Yamato,Norio Shiba,Kenichi Yoshida,Yusuke Hara,Yuichi Shiraishi,Kentaro Ohki,Manabu Sotomatsu,Hirokazu Arakawa,Hidemasa Matsuo,Akira Shimada,Tomohiko Taki,Nobutaka Kiyokawa,Daisuke Tomizawa,Keizo Horibe,Satoru Miyano,Souichi Adachi,Ta;Yusuke Hara,Tomohiko Taki,Genki Yamato,Kenichi Yoshida,Norio Shiba,Taeko Kaburagi,Yuichi Shiraishi,Kentaro Ohki,Machiko Kawamura,Manabu Sotomatsu,Hirokazu Arakawa,Hidemasa Matsuo,Akira Shimada,Nobutaka Kiyokawa,Daisuke Tomizawa,Takashi Taga,Keizo Horibe,S;Kana Nakatani,Hidemasa Matsuo,Yuki Morimoto,Yasuhiko Kamikubo,Souichi Adachi;Taeko Kaburagi,Genki Yamato,Norio Shiba,Kenichi Yoshida,Yusuke Hara,Yuichi Shiraishi,Kentaro Ohki,Manabu Sotomatsu,Hirokazu Arakawa,Hidemasa Matsuo,Akira Shimada,Tomohiko Taki,Nobutaka Kiyokawa,Daisuke Tomizawa,Keizo Horibe,Satoru Miyano,Souichi Adachi,Ta;松尾英将,吉田健一,中谷香菜,上久保靖彦,小川誠司,足立壯一;能浦三奈,森田剣,清瀬大樹,立田俊也,松尾英将,上久保靖彦,足立壯一;増田達哉,片岡竜貴,立田俊也,松尾英将,杉山弘,足立壯一,上久保靖彦;小林紫乃,佐々木亜沙美,沖中えり佳,武田佳那子,武田瑞穂,松尾英将,野口勇貴,杉山弘,足立壯一,上久保靖彦;沖中えり佳,小林紫乃,武田瑞穂,佐々木亜沙美,武田佳那子,松尾英将,足立壯一,上久保靖彦
• 通讯作者: 沖中えり佳,小林紫乃,武田瑞穂,佐々木亜沙美,武田佳那子,松尾英将,足立壯一,上久保靖彦