Potential mechanism of Gadolinium penetration via intact blood-brain barriers and the effect of Gd retention to brain cancer proliferation

钆穿过完整血脑屏障渗透的潜在机制以及钆保留对脑癌增殖的影响

• 批准号: 19K17224
• 负责人: Kartamihardja Achmad
• 金额: $ 1.66万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K17224/
• 关键词: Gadolinium; GBCA; Gadolinium retention; GDD; NSF; choroid plexus; contrast agents; Transmetallation; Gadolinium deposition; neutrophil elastase; astroglioma; meduloblastoma; Contrast agents (GBCA); Fe(II); Purkinje cells; Gadolinium toxicit

项目成果

Quantitative analysis of Gd in the protein content of the brain following single injection of gadolinium-based contrast agents (GBCAs) by size exclusion chromatography

• DOI: 10.1259/bjr.20190062
• 发表时间: 2019-01-01
• 期刊: BRITISH JOURNAL OF RADIOLOGY
• 影响因子: 2.6
• 作者: Kartamihardja, Achmad Adhipatria Perayabangsa;Hanaoka, Hirofumi;Tsushima, Yoshito
• 通讯作者: Tsushima, Yoshito

Changes in the purkinje cell's synaptic density after GBCA exposure: an in-vitro study

GBCA 暴露后浦肯野细胞突触密度的变化：一项体外研究

• 发表时间: 2019
• 作者: Yusuke Urushihara;Takuma Hashimoto;Yasuhiko Murata;Yohei Fujishima;Kazuya Takeda;Soichiro Shiga;Kanna Kudo;Yaoki Sonohara;Yoshio Hosoi;大彌 歩;Achmad Adhipatria Perayabangsa Kartamihardja
• 通讯作者: Achmad Adhipatria Perayabangsa Kartamihardja

Quantitative analysis of gadolinium in the protein content of the brain post-administration of gadopentetate

钆喷酸给药后大脑蛋白质含量中钆的定量分析

• 发表时间: 2019
• 作者: MURAI TARO;TAMURA TAKESHI;NAKABAYASHI TADASHI;ITO HIROYA;MANABE YOSHIHIKO;MURATA RUMI;NIWA MASANARI;SHIBAMOTO YUTA;梅野 凌，岩﨑遼太，吉川竜太郎，森 崇，鈴木 実;Achmad Adhipatria Perayabangsa Kartamihardja
• 通讯作者: Achmad Adhipatria Perayabangsa Kartamihardja

Immuno-PET imaging for non-invasive assessment of cetuximab accumulation in non-small cell lung cancer

• DOI: 10.1186/s12885-019-6238-4
• 发表时间: 2019-10-24
• 期刊: BMC CANCER
• 影响因子: 3.8
• 作者: Yamaguchi, Aiko;Achmad, Arifudin;Tsushima, Yoshito
• 通讯作者: Tsushima, Yoshito

Changes in the Purkinje cell’s synaptic density post-incubation of gadobutrol and ferrous ion: an in-vitro study

钆布醇和亚铁离子孵育后浦肯野细胞突触密度的变化：一项体外研究

• 发表时间: 2020
• 作者: 鈴木悠史;梶田大樹;呉アンナ;竹丸雅志;岡部圭介;今西宣晶;浅尾恭史;八木隆行;相磯貞和;貴志和生;Achmad Adhipatria Perayabangsa Kartamihardja
• 通讯作者: Achmad Adhipatria Perayabangsa Kartamihardja