Toxicity Reduction with Antifungal Prophylaxis during Chemoradiotherapy for Head and Neck Cancer

头颈癌放化疗期间抗真菌预防可降低毒性

• 批准号: 19K17262
• 负责人: 齋藤 紘丈
• 金额: $ 2.58万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K17262/
• 关键词: 口腔粘膜炎; 倫理審査; データマネジメント準備; 後方視的研究; 口腔咽頭カンジダ症

2019年度は特定臨床研究「フルコナゾール投与による口腔粘膜炎の予防を目的とした臨床試験」の準備にあたり、臨床研究推進センターと共同でデータ入力システムの構築および論文作成を行った。2019年度末に研究代表者が精神疾患を発症し2020年度は研究活動を休止していた。2021年1月末をもって研究代表者が退職することとなり、廃止申請を行った。

In 2019, the preparation and clinical research of the specific clinical study "Oral Mucositis Prevention Objective" were carried out. The end of the year 2019, the representative of the study was diagnosed with mental illness, and the end of the year 2020, the research activities were suspended. At the end of January 2021, the research representative resigned and the application was terminated.

项目成果

Dramatic response of BRAF V600E-mutant epithelioid glioblastoma to combination therapy with BRAF and MEK inhibitor: establishment and xenograft of a cell line to predict clinical efficacy

• DOI: 10.1186/s40478-019-0774-7
• 发表时间: 2019-07-25
• 期刊: ACTA NEUROPATHOLOGICA COMMUNICATIONS
• 影响因子: 7.1
• 作者: Kanemaru, Yu;Natsumeda, Manabu;Fujii, Yukihiko
• 通讯作者: Fujii, Yukihiko

The association between oral candidiasis and severity of chemoradiotherapy-induced dysphagia in head and neck cancer patients: A retrospective cohort study

头颈癌患者口腔念珠菌病与放化疗引起的吞咽困难严重程度之间的关联：一项回顾性队列研究

• DOI: 10.1016/j.ctro.2019.10.006
• 发表时间: 2020
• 期刊: Clinical and Translational Radiation Oncology
• 影响因子: 3.1
• 作者: Hirotake Saito;Ryusuke Shodo;Keisuke Yamazaki;Kouji Katsura;Yushi Uek;Toshimichi Nakano;Tomoya Oshikane;Nobuko Yamana;Satoshi Tanabe;Satoru Utsunomiya;Atsushi Ohta;Eisuke Abe;Motoki Kaidu;Ryuta Sasamoto;Hidefumi Aoyama
• 通讯作者: Hidefumi Aoyama

Selection criteria for 3D conformal radiotherapy versus volumetric-modulated arc therapy in highgrade glioma based on normal tissue complication probability of brain

基于脑部正常组织并发症概率的高级别胶质瘤3D适形放射治疗与体积调制弧形治疗的选择标准

• DOI: 10.1093/jrr/rry106
• 发表时间: 2019
• 期刊: Journal of Radiation Research
• 影响因子: 2
• 作者: Satoshi Tanabe;Haruna Takahashi;Hirotake Saito;Atsushi Ohta;Toshimichi Nakano;Ryuta Sasamoto;Miki Shioi;Satoru Utsunomiya;Eisuke Abe;Motoki Kaidu;Hidefumi Aoyama
• 通讯作者: Hidefumi Aoyama