Differential effects of small size gold nanoparticles on radiation and ultrasound-induce cell death

小尺寸金纳米粒子对辐射和超声诱导细胞死亡的不同影响

• 批准号: 19K17263
• 负责人: ジャベド パラス
• 金额: $ 2.66万
• 依托单位: University of Toyama
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K17263/
• 关键词: Reactive Oxygen Species; GSH; Gold Nanoparticles; Cold Atmospheric Plasma; Apoptosis; Gold nanoparticles; Radiation; 放射線

The main objective of this study is to identify the role of various sizes of Au-NPs with physical modalities, as Au-NPs are considered fully multifunctional, so preferred over other metal nanoparticles. In this study, only small size Au-NPs can enhance He-CAP induced apoptosis due to the decrease of intracellular GSH levels that leads to excessive generation of intracellular ROS. ROS mediated damage to intracellular components initiate the apoptotic cell death either by intrinsic or extrinsic apoptotic pathways. These findings highlight the importance of determining the Au-NPs size dependent effects with CAP on various cancer cells. The complex phenomena and contradictory reports on Au-NPs size make it essential to develop an optimized design of Au-NPs for future CAP therapy. The results have been published in a form of original article in the Journal Cell Death and Discovery.

本研究的主要目的是确定各种尺寸的Au-NPs与物理方式的作用，因为Au-NPs被认为是完全多功能的，因此优于其他金属纳米颗粒。在这项研究中，只有小尺寸的Au-NPs可以增强He-CAP诱导的细胞凋亡，这是由于细胞内GSH水平的降低导致细胞内ROS的过度产生。ROS介导的对细胞内组分的损伤通过内源性或外源性凋亡途径启动凋亡性细胞死亡。这些发现强调了确定CAP对各种癌细胞的Au-NPs大小依赖性效应的重要性。复杂的现象和相互矛盾的报告金纳米粒子的大小，使它有必要开发一个优化的设计金纳米粒子为未来的CAP治疗。研究结果以原创文章的形式发表在《细胞死亡与发现》杂志上。

项目成果

Small size gold nanoparticles enhance apoptosis-induced by cold atmospheric plasma via depletion of intracellular GSH and modification of oxidative stress

• DOI: 10.1038/s41420-020-00314-x
• 发表时间: 2020-09-10
• 期刊: CELL DEATH DISCOVERY
• 影响因子: 7
• 作者: Jawaid, Paras;Rehman, Mati Ur;Kondo, Takashi
• 通讯作者: Kondo, Takashi