Pharmacokinetics of post-transplant cyclophosphamide and its active metabolite for pediatric hematopoietic stem cell transplantation

移植后环磷酰胺及其活性代谢物在小儿造血干细胞移植中的药代动力学

• 批准号: 19K17316
• 负责人: Utano Tomoyuki
• 金额: $ 2.66万
• 依托单位: National Center for Child Health and Development
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K17316/
• 关键词: PTCY; pharmacokinetics; cyclophosphamide; child; voriconazole; busulfan; シクロホスファミド; 小児; 血中濃度

项目成果

Two-point blood sampling is sufficient and necessary to estimate the area under the concentration-time curve for intravenous busulfan in infants and young children.

两点采血足以估计婴儿和幼儿静脉注射白消安的浓度-时间曲线下面积。

• DOI: 10.1002/pbc.29069
• 发表时间: 2021
• 期刊: Pediatr Blood Cancer
• 影响因子: 3.2
• 作者: Utano T;Kato M;Sakamoto K;Osumi T;Matsumoto K;Tomizawa D;Matsumoto K;Yamatani A.
• 通讯作者: Yamatani A.

Effects of voriconazole on the pharmacokinetics of cyclophosphamide in children's cancer patients

伏立康唑对儿童癌症患者环磷酰胺药动学的影响

• 发表时间: 2022
• 作者: Tomoyuki Utano;Motohiro Kato;Akira Takebayashi;Shin-Ichi Tsujimoto;Reo Tanoshima;Hirotoshi Sakaguchi;Akihiro Iguchi;Daisuke Tomizawa;Kimikazu Matsumoto;Akimasa Yamatani
• 通讯作者: Akimasa Yamatani