Elucidation of the role of hematopoietic cells in the development and progression of liver cirrhosis due to NASH and establishment of new therapeutic targets.

阐明造血细胞在NASH引起的肝硬化发生和进展中的作用并建立新的治疗靶点。

• 批准号: 19K17404
• 负责人: Ozono Yoshinori
• 金额: $ 2.75万
• 依托单位: University of Miyazaki
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K17404/
• 关键词: NASH; 肝硬変; fibrocyte; CDAHFD; CD11b-DTR; fibroycyte; clodronate liposome; TET2; 非アルコール性脂肪肝炎

项目成果

Depletion of Neoplastic CD11b Positive Cells in Jak2V617F Mutant Mice Reduced Fibrocytes in Bone Marrow and Improved Myelofibrosis

Jak2V617F 突变小鼠中肿瘤性 CD11b 阳性细胞的耗竭减少了骨髓中的纤维细胞并改善了骨髓纤维化

• 发表时间: 2019
• 作者: Fujiwara H;Tateishi K;Misumi K;Hayashi A;Igarashi K;Kato H;Nakatsuka T;Suzuki N;Yamamoto K;Kudo Y;Hayakawa Y;Nakagawa ;Tanaka Y;Ijichi H;Kogure H;Nakai Y;Isayama H;Hasegawa K;Fukayama M;Soga T;Koike K;Kazuya Shimoda
• 通讯作者: Kazuya Shimoda

Monocyte-derived fibrocytes elimination had little contribution on liver fibrosis

单核细胞来源的纤维细胞消除对肝纤维化影响不大

• DOI: 10.1016/j.hbpd.2019.02.002
• 发表时间: 2019
• 期刊: Hepatobiliary & Pancreatic Diseases International
• 影响因子: 3.3
• 作者: Ozono Yoshinori;Shide Kotaro;Toyoshima Fumiyo;Takaishi Yuuka;Tsuchimochi Mai;Kamiunten Ayako;Kameda Takuro;Nakamura Kenichi;Miike Tadashi;Kusumoto Kazunori;Iwakiri Hisayoshi;Hasuike Satoru;Nagata Kenji;Sawaguchi Akira;Shimoda Kazuya
• 通讯作者: Shimoda Kazuya