Cell-mediated immunity induction by anti-HER2 antibody treatment for HER2-positive breast cancer and development of new immunotherapy

抗 HER2 抗体治疗 HER2 阳性乳腺癌的细胞介导免疫诱导及新免疫疗法的开发

• 批准号: 19K18051
• 负责人: Kitamura Mina
• 金额: $ 2.66万
• 依托单位: Shiga University of Medical Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K18051/
• 关键词: 免疫治療; 乳癌薬物療法; 腫瘍浸潤リンパ球; 抗HER2抗体; 免疫チェックポイント阻害剤; 免疫逃避; 細胞性免疫; TIL; DOC; HER2; CTL; 免疫チェックポイント阻害; 細胞性免疫誘導; 乳がん

项目成果

Effect of hyperthermia on the cancer stem-like cells

热疗对癌症干细胞样细胞的影响

• 发表时间: 2020
• 作者: Miyuki Shimoji;Satoshi Murata;Andreas Michael Sihombing;Katsushi Takebayashi;Hirokazu Kodama;Masatsugu Kojima;Tomoyuki Ueki;Naomi Kitamura;Mina Kitamura;Aya Tokuda;Toru Miyake;Eiji Mekata;Masaji Tani.
• 通讯作者: Masaji Tani.

Characterization of Tumor-associated lymphocytes (TAL) in malignant ascites of immune-tolerant mice

免疫耐受小鼠恶性腹水中肿瘤相关淋巴细胞 (TAL) 的表征

• 发表时间: 2021
• 作者: Miyuki Shimoji 1);Satoshi Murata 2);Masatsugu Kojima 1);Mina Kitamura 1);Andreas Michael Sihombing 1);Sakura Nakao 1);Naomi Kitamura 3);Tomoyuki Ueki 1);Katsushi Takebayashi 1);Hirokazu Kodama 1);Aya Tokuda 1);Toru Miyake 1);Eiji Mekata 3);Ma
• 通讯作者: Ma

Overcoming immune tolerance to tumor antigens and inducing tumor antigen-specific CTLs by combined immunotherapy

通过联合免疫疗法克服对肿瘤抗原的免疫耐受并诱导肿瘤抗原特异性CTL

• 发表时间: 2021
• 作者: Sakura Nakao;Satoshi Murata;Miyuki Shimoji;Masatsugu Kojima;Mina Kitamura;Andreas Michael Sihombing;Naomi Kitamura;Tomoyuki Ueki;Katsushi Takebayashi;Hirokazu Kodama;Aya Tokuda;Toru Miyake;Eiji Mekata;Masaji Tani
• 通讯作者: Masaji Tani

Induction of tumor Ag-specific CTL using tumor-associated lymphocytes (TAL) in malignant ascites of immune-tolerant mice

使用肿瘤相关淋巴细胞 (TAL) 在免疫耐受小鼠的恶性腹水中诱导肿瘤 Ag 特异性 CTL

• 发表时间: 2021
• 作者: Satoshi Murata;Miyuki Shimoji;Masatsugu Kojima;Mina Kitamura;Andreas Michael Sihombing;Sakura Nakao;Naomi Kitamura;Tomoyuki Ueki;Katsushi Takebayashi;Hirokazu Kodama;Aya Tokuda;Toru Miyake;Eiji Mekata;Masaji Tani
• 通讯作者: Masaji Tani

Therapeutic strategy based on the mechanism of peritoneal relapse after surgery for gastric cancer

基于胃癌术后腹膜复发机制的治疗策略

• 发表时间: 2020
• 作者: Satoshi Murata;Katsushi Takebayashi;Tsuyoshi Yamaguchi;Sachiko Kaida;Ken Ishikawa;Hirokazu Kodama;Miyuki Shimoji;Andreas Michael Sihombing;Masatsugu Kojima;Toru Miyake;Hiroya Iida;Tomoyuki Ueki;Mina Kitamura;Aya Tokuda;Eiji Mekata;Masaji Ta
• 通讯作者: Masaji Ta