Flotillins in the regulation of desmosomal adhesion in pemphigus

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Cell-cell adhesion in the epidermis is of vital importance for the function of the skin as a barrier, and aberrant adhesion can result in severe human diseases. Therefore, it is important to understand the molecular mechanisms that regulate epidermal cell adhesion. In this project, we will study the role of the members of the flotillin protein family in desmosomal adhesion. We have shown that flotillins can form complexes with desmosomal adhesion proteins and regulate their expression. Here, we will study how flotillins influence the dynamics of desmosomal adhesion and which role do they play in pemphigus pathogenesis. A special focus will be laid on cellular trafficking steps of the desmosomal adhesion proteins, as well as on signalling events induced by pemphigus autoantibodies and their dependence on flotillins.