Elucidation of the pathophysiology of Leber's congenital amaurosis using genome editing technology

利用基因组编辑技术阐明莱伯先天性黑蒙的病理生理学

• 批准号: 19K18878
• 负责人: Hosokawa Mio
• 金额: $ 2.66万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K18878/
• 关键词: レーバー先天黒内障; KCNJ13遺伝子; ゲノム編集; アポトーシス; ネクローシス; 走査型電子顕微鏡

项目成果

KCNJ13 gene deletion impairs phagocytosis in retinal pigment epithelium derived from human-induced pluripotent stem cells.

KCNJ13 基因缺失会损害源自人诱导多能干细胞的视网膜色素上皮的吞噬作用。

• 发表时间: 2020
• 作者: 河嶋瑠美;松下賢治;馬場圭太;西田幸二;Yuki Kanzaki; Hirofumi Fujita; Keita Sato; Mio Hosokawa; Hiroshi Matsumae; Fumio Shiraga; Yuki Morizane; Hideyo Ohuchi
• 通讯作者: Yuki Kanzaki; Hirofumi Fujita; Keita Sato; Mio Hosokawa; Hiroshi Matsumae; Fumio Shiraga; Yuki Morizane; Hideyo Ohuchi

KCNJ13 Gene Deletion Impairs Cell Alignment and Phagocytosis in Retinal Pigment Epithelium Derived from Human-Induced Pluripotent Stem Cells

• DOI: 10.1167/iovs.61.5.38
• 发表时间: 2020-05-01
• 期刊: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
• 影响因子: 4.4
• 作者: Kanzaki, Yuki;Fujita, Hirofumi;Ohuchi, Hideyo
• 通讯作者: Ohuchi, Hideyo