Exploratory research for effective application of molecular targeted drugs by analysis of regulatory T cell variation in oral cancer treatment

通过分析调节性T细胞变异在口腔癌治疗中有效应用分子靶向药物的探索性研究

• 批准号: 19K18968
• 负责人: Fukumoto Chonji
• 金额: $ 2.75万
• 依托单位: Dokkyo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K18968/
• 关键词: 口腔癌; 制御性T細胞; 分子標的薬; 腫瘍免疫; 抗体依存性細胞障害活性; 抗体依存性細胞障害

项目成果

Bone marrow-derived cells conribute to develop squamous cell carcinoma

骨髓来源的细胞有助于发展鳞状细胞癌

• 发表时间: 2019
• 作者: Yuta Sawatani;Yusuke Komiyama;Ryouta Kamimura;Michiko Shimura;Tomonori Hasegawa;Chonji Fukumoto;Atsushi Fujita;Takahiro Wakui;Hitoshi Kawamata
• 通讯作者: Hitoshi Kawamata

Clinical characteristics, treatment methods and prognoses of patients with oral squamous cell carcinoma in Japanese population: a single institution retrospective cohort study.

• DOI: 10.1186/s12877-020-01902-3
• 发表时间: 2020-11-20
• 期刊: BMC geriatrics
• 影响因子: 4.1
• 作者: Fukumoto C;Ogisawa S;Tani M;Hyodo T;Kamimura R;Sawatani Y;Hasegawa T;Komiyama Y;Fujita A;Wakui T;Haruyama Y;Kobashi G;Kawamata H
• 通讯作者: Kawamata H

A retrospective cohort study: Effectiveness of preemptive postsurgical therapy by cetuximab for oral squamous cell carcinoma patients with major risk

一项回顾性队列研究：西妥昔单抗抢先术后治疗对高危口腔鳞状细胞癌患者的有效性

• 发表时间: 2021
• 作者: Chonji Fukumoto;Toshiki Hyodo;Ryo Oshima;Yuta Sawatani;Ryo Shiraishi;Ryouta Kamimura;Sayaka Izumi;Takahiro Wakui;Atsushi Fujita;Hitoshi Kawamata
• 通讯作者: Hitoshi Kawamata

Paclitaxel potentiated the anticancer effect of cetuximab via enhancing the antibody-dependent cellular cytotoxicity on oral squamous cell carcinoma cells in vitro.

紫杉醇通过增强体外对口腔鳞状细胞癌细胞的抗体依赖性细胞毒性来增强西妥昔单抗的抗癌作用。

• 发表时间: 2020
• 作者: Sawatani Yuta;Komiyama Yuske;Kamimura Ryouta;Shimura Michiko;Hasegawa Tomonori;Fukumoto Chonji;Kuribayashi Nobuyuki;Fujita Atsushi;Wakui Takahiro;Nakashiro Koh-ichi;Uchida Daisuke;Kawamata Hitoshi
• 通讯作者: Kawamata Hitoshi

口腔扁平上皮癌患者の治療後イベント(再発,転移)発生リスク因子とサーベイランス

口腔鳞状细胞癌患者治疗后事件（复发、转移）的危险因素和监测

• 发表时间: 2020
• 作者: Roy RR;Shimada K;Murakami S;Hasegawa H;福本正知，澤谷祐大，上村亮太，長谷川智則，八木沢就真，齋藤正浩，大久保真希，藤田温志，和久井崇大，川又均
• 通讯作者: 福本正知，澤谷祐大，上村亮太，長谷川智則，八木沢就真，齋藤正浩，大久保真希，藤田温志，和久井崇大，川又均