Association of activity changes in the motor cortex and lower motor neuron with anti-spastic effect of the vibratory stimulation

运动皮层和下运动神经元的活动变化与振动刺激的抗痉挛作用的关联

• 批准号: 19K19892
• 负责人: 野間 知一
• 金额: $ 2.66万
• 依托单位: Nihon Fukushi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K19892/
• 关键词: 振動刺激; 筋緊張測定; メカニズム

申請者は、振動刺激の痙縮抑制メカニズムに大脳皮質の変化と脊髄の変化、およびその相互作用が寄与すると着目している。計画立案当初は、3年間の研究期間に様々な振動刺激条件での中枢神経への影響を大脳皮質と脊髄の両面でとらえられる実験装置を作成し、健常者および痙縮患者を対象に検証する計画であった。 2019年度は、実験装置の作成が完了した。機能としては①筋緊張の張力をリアルタイムに測定する機能や②市販の様々なバイブレーターを掴み適切に前腕や手掌にあてる機能、③測定者の手の大きさに合わせてワンタッチで調整可能でさらに固定した後は決して外れない安全機能、④手首を任意の角度で止める機能などを取り入れることに成功した。2020年度は安全性の確認、健常者を対象にした大脳皮質と脊髄への影響を調べる予定であった。結果としては安全性の確認、実験装置 に含まれる緊張力測定装置の再現性等の確認は実施できたものの、測定機材の不備や故障と新型コロナ感染症に伴う人を対象とした実験の実行が難しかったことから大幅に遅れた。2021年度に入り機材の問題は解決したが、その機材に慣れる時間を要したことと新型コロナ感染症の問題は継続した。2022年度も新型コロナ感染症に伴う人を対象とした実験の実行が難しかったこと、申請者が新型コロナ感染症への対応から業務多忙となり適切な研究時間の確保しづらくなったことなど複合的な要因により研究が遅れることとなった。そのため研究期間をさらに1年延長する申請を行なった。

The applicant, the vibration stimulation, the suppression, the dermatology, the spinal cord, the interaction, the interaction, and the attention. At the beginning of the project, during the three-year study period, the central nervous system was involved in the study of vibration stimulation conditions. during the three-year and three-year study period, the central nervous system was successfully completed, and the normal people were able to treat patients like those in the hospital. In 2019, the equipment has been completed. The machine can be used to measure the mechanical strength of the machine. 2, the front wrist is cut, the palm of the wrist is cut, the machine is powered, and the machine is adjusted. It is possible to change the safety of foreign equipment after fixing the machine. 4 the first hand can be used at any angle and the machine will be able to enter the machine successfully. In 2020, those who are safe and healthy are expected to know that they are safe and healthy. Results the safety of the equipment was confirmed, the equipment was equipped with the equipment to determine the reproducibility of the equipment, and the equipment was used to determine the safety of the equipment. The equipment and materials were not equipped for malfunction. The new type of infectious disease was accompanied by a large number of people, such as the equipment, equipment and equipment. In the year 2021, it is necessary to solve the problem of infectious disease of the new type of infectious disease in the year 2021. In the year 2022, people with a new type of infectious disease, such as those who were infected with a new type of infectious disease, and those who applied for a new type of infectious disease, did a lot of research on how busy they were and how busy they were during the study time. During the study period, we will extend the application for an one-year extension of the study.