Evaluation of Potential Role of Olive Leaf Extract as A Natural Way to Prevent and Improve Anemia: A randomized Clinical Trial in Japan and Tunisia

橄榄叶提取物作为预防和改善贫血的自然方法的潜在作用的评估：在日本和突尼斯进行的随机临床试验

• 批准号: 19K20106
• 负责人: FERDOUSI FARHANA
• 金额: $ 2.66万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K20106/
• 关键词: Olive leaf extract; Anemia; Hemoglobin; Natural compound; anemia; hematological parameter; hemoglobin; Olive leaf tea; Clinical trial

Total 333 participants have been assessed for eligibility for the olive leaf extract intervention study. Among them 273 were qualified for baseline hematological assessment. Finally, 165 participants were randomized in three groups, including one placebo and two intervention groups. Total 157 participants completed 12-weeks of intervention.

共有333名参与者接受了橄榄叶提取物干预研究的资格评估。其中273例符合基线血液学评估要求。最后，165名参与者被随机分为三组，包括一个安慰剂组和两个干预组。共有157名参与者完成了为期12周的干预。

项目成果

Directing stem cell fate using plant extracts and their bioactive compounds

使用植物提取物及其生物活性化合物指导干细胞命运

• 发表时间: 2023
• 作者: Hiroko Isoda;Francis G. Szele;Yun-Wen Zheng;DongZhu Xu;Kazunori Sasaki and Farhana Ferdousi
• 通讯作者: Kazunori Sasaki and Farhana Ferdousi

Effects of Oral Intake of Olive Leaf Extract on Hematological Parameters: A Double-Blinded, Randomized, Placebo-Controlled Trial in Progress

口服橄榄叶提取物对血液学参数的影响：正在进行的双盲、随机、安慰剂对照试验

• DOI: 10.1182/blood-2021-149587
• 发表时间: 2021
• 期刊: Blood
• 影响因子: 20.3
• 作者: Ferdousi Farhana;Alam Masud;Araki Risa;Suidasari Sofya;Yokozawa Miki;Yamauchi Ken;Hashimoto Koichi;Haque Rashidul;Isoda Hiroko
• 通讯作者: Isoda Hiroko

Olive Leaf Exact Promotes Recovery from Phenylhydrazine-Induced Acute Hemolytic Anemia in Mice

橄榄叶提取物促进小鼠苯肼引起的急性溶血性贫血的恢复

• 发表时间: 2022
• 作者: Jinchang Zhao;Shinji Kondo;Sofya Suidasari;Miki Yokozawa;Ken Yamauchi;Mohamed Moncef Harrabi;Farhana Ferdousi;Hiroko Isoda
• 通讯作者: Hiroko Isoda

Integrated Transcriptome Analysis of Human Amniotic Epithelial Stem Cells Treated with Plant Extracts and Their Bioactive Compounds: A 3 in 1 Approach to Explore Biological Activities

用植物提取物及其生物活性化合物处理的人羊膜上皮干细胞的综合转录组分析：探索生物活性的三合一方法

• 发表时间: 2022
• 作者: Farhana Ferdousi;Hiroko Isoda
• 通讯作者: Hiroko Isoda

An Integrated Transcriptome Analysis Reveals Erythropoietic Potential of Olive Leaf in Human Hematopoietic Stem Cells

综合转录组分析揭示了橄榄叶在人类造血干细胞中的红细胞生成潜力

• 发表时间: 2020
• 作者: Shinji Kondo;Farhana Ferdousi;Ken Yamauchi;Sofya Suidasari;Miki Yokozawa;Moncef Harrabi;Ken-ichi Tominaga;Hiroko Isoda
• 通讯作者: Hiroko Isoda